2a49
From Proteopedia
(Difference between revisions)
												
			
			| Line 1: | Line 1: | ||
| ==Crystal structure of clavulanic acid bound to E166A variant of SHV-1 beta-lactamase== | ==Crystal structure of clavulanic acid bound to E166A variant of SHV-1 beta-lactamase== | ||
| - | <StructureSection load='2a49' size='340' side='right' caption='[[2a49]], [[Resolution|resolution]] 1.43Å' scene=''> | + | <StructureSection load='2a49' size='340' side='right'caption='[[2a49]], [[Resolution|resolution]] 1.43Å' scene=''> | 
| == Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2a49]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2a49]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A49 FirstGlance]. <br> | 
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene>, <scene name='pdbligand=TEM:N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE'>TEM</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene>, <scene name='pdbligand=TEM:N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE'>TEM</scene></td></tr> | 
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rcj|1rcj]], [[2a3u|2a3u]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rcj|1rcj]], [[2a3u|2a3u]]</div></td></tr> | 
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla, shv1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla, shv1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr> | 
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | 
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a49 OCA], [https://pdbe.org/2a49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a49 RCSB], [https://www.ebi.ac.uk/pdbsum/2a49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a49 ProSAT]</span></td></tr> | 
| </table> | </table> | ||
| == Evolutionary Conservation == | == Evolutionary Conservation == | ||
| Line 14: | Line 14: | ||
| Check<jmol> | Check<jmol> | ||
|   <jmolCheckbox> |   <jmolCheckbox> | ||
| - |     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a49_consurf.spt"</scriptWhenChecked> | + |     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a49_consurf.spt"</scriptWhenChecked> | 
|     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
|     <text>to colour the structure by Evolutionary Conservation</text> |     <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 29: | Line 29: | ||
| </div> | </div> | ||
| <div class="pdbe-citations 2a49" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2a49" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | ||
| == References == | == References == | ||
| <references/> | <references/> | ||
| Line 34: | Line 37: | ||
| </StructureSection> | </StructureSection> | ||
| [[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
| + | [[Category: Large Structures]] | ||
| [[Category: Akker, F van den]] | [[Category: Akker, F van den]] | ||
| [[Category: Bonomo, R A]] | [[Category: Bonomo, R A]] | ||
Revision as of 08:25, 27 January 2021
Crystal structure of clavulanic acid bound to E166A variant of SHV-1 beta-lactamase
| 
 | |||||||||||

