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1yl2

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[[Image:1yl2.jpg|left|200px]]
[[Image:1yl2.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_1yl2| PDB=1yl2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yl2 OCA], [http://www.ebi.ac.uk/pdbsum/1yl2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yl2 RCSB]</span>
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'''Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family- Structural and functional characterization'''
'''Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family- Structural and functional characterization'''
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==About this Structure==
==About this Structure==
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1YL2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YL2 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YL2 OCA].
==Reference==
==Reference==
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization., Bayrhuber M, Vijayan V, Ferber M, Graf R, Korukottu J, Imperial J, Garrett JE, Olivera BM, Terlau H, Zweckstetter M, Becker S, J Biol Chem. 2005 Jun 24;280(25):23766-70. Epub 2005 Apr 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15833744 15833744]
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization., Bayrhuber M, Vijayan V, Ferber M, Graf R, Korukottu J, Imperial J, Garrett JE, Olivera BM, Terlau H, Zweckstetter M, Becker S, J Biol Chem. 2005 Jun 24;280(25):23766-70. Epub 2005 Apr 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15833744 15833744]
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[[Category: Conus striatus]]
 
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[[Category: Protein complex]]
 
[[Category: Bayrhuber, M.]]
[[Category: Bayrhuber, M.]]
[[Category: Becker, S.]]
[[Category: Becker, S.]]
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[[Category: Vijayan, V.]]
[[Category: Vijayan, V.]]
[[Category: Zweckstetter, M.]]
[[Category: Zweckstetter, M.]]
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[[Category: kunitz-domain]]
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[[Category: Kunitz-domain]]
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[[Category: neurotoxin]]
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[[Category: Neurotoxin]]
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[[Category: potassium channel blocker]]
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[[Category: Potassium channel blocker]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:27:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:11:30 2008''
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Revision as of 13:27, 3 May 2008

Image:1yl2.jpg

Template:STRUCTURE 1yl2

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family- Structural and functional characterization


Overview

Conkunitzin-S1 (Conk-S1) is a 60-residue neurotoxin from the venom of the cone snail Conus striatus that interacts with voltage-gated potassium channels. Conk-S1 shares sequence homology with Kunitz-type proteins but contains only two out of the three highly conserved cysteine bridges, which are typically found in these small, basic protein modules. In this study the three-dimensional structure of Conk-S1 has been solved by multidimensional NMR spectroscopy. The solution structure of recombinant Conk-S1 shows that a Kunitz fold is present, even though one of the highly conserved disulfide cross-links is missing. Introduction of a third, homologous disulfide bond into Conk-S1 results in a functional toxin with similar affinity for Shaker potassium channels. The affinity of Conk-S1 can be enhanced by a pore mutation within the Shaker channel pore indicating an interaction of Conk-S1 with the vestibule of potassium channels.

About this Structure

Full crystallographic information is available from OCA.

Reference

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization., Bayrhuber M, Vijayan V, Ferber M, Graf R, Korukottu J, Imperial J, Garrett JE, Olivera BM, Terlau H, Zweckstetter M, Becker S, J Biol Chem. 2005 Jun 24;280(25):23766-70. Epub 2005 Apr 15. PMID:15833744 Page seeded by OCA on Sat May 3 16:27:20 2008

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