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1ymf

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[[Image:1ymf.gif|left|200px]]
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{{Structure
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|RELATEDENTRY=[[1yks|1YKS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ymf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ymf OCA], [http://www.ebi.ac.uk/pdbsum/1ymf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ymf RCSB]</span>
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'''crystal structure of yellow fever virus NS3 helicase complexed with ADP'''
'''crystal structure of yellow fever virus NS3 helicase complexed with ADP'''
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[[Category: Smith, J L.]]
[[Category: Smith, J L.]]
[[Category: Wu, J.]]
[[Category: Wu, J.]]
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[[Category: Adp]]
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[[Category: atpase]]
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[[Category: Atpase]]
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[[Category: dead-box]]
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[[Category: Dead-box]]
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[[Category: flavivirus]]
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[[Category: Flavivirus]]
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[[Category: helicase]]
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[[Category: Helicase]]
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[[Category: rtpase]]
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[[Category: Rtpase]]
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[[Category: yellow fever virus]]
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[[Category: Yellow fever virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:30:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:13:12 2008''
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Revision as of 13:30, 3 May 2008

Image:1ymf.gif

Template:STRUCTURE 1ymf

crystal structure of yellow fever virus NS3 helicase complexed with ADP


Overview

Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.

About this Structure

1YMF is a Single protein structure of sequence from Yellow fever virus. Full crystallographic information is available from OCA.

Reference

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:16051820 Page seeded by OCA on Sat May 3 16:30:31 2008

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