1ymt
From Proteopedia
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[[Image:1ymt.gif|left|200px]] | [[Image:1ymt.gif|left|200px]] | ||
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'''Mouse SF-1 LBD''' | '''Mouse SF-1 LBD''' | ||
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[[Category: Willson, T M.]] | [[Category: Willson, T M.]] | ||
[[Category: Xu, R X.]] | [[Category: Xu, R X.]] | ||
| - | [[Category: | + | [[Category: Co-repressor peptide]] |
| - | [[Category: | + | [[Category: Ligand]] |
| - | [[Category: | + | [[Category: Ligand-binding domain]] |
| - | [[Category: | + | [[Category: Nuclear receptor]] |
| - | [[Category: | + | [[Category: Phosphatidyl glycerol]] |
| - | [[Category: | + | [[Category: Sf-1]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:31:17 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:31, 3 May 2008
Mouse SF-1 LBD
Overview
Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors.
About this Structure
1YMT is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1., Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA, Cell. 2005 Feb 11;120(3):343-55. PMID:15707893 Page seeded by OCA on Sat May 3 16:31:17 2008
