1yok

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1yok.gif|left|200px]]
[[Image:1yok.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1yok |SIZE=350|CAPTION= <scene name='initialview01'>1yok</scene>, resolution 2.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_1yok", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=P6L:(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL+(8E)-OCTADEC-8-ENOATE'>P6L</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= NR5A2, B1F, CPF, FTF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1yok| PDB=1yok | SCENE= }}
-
|RELATEDENTRY=[[1ymt|1YMT]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yok OCA], [http://www.ebi.ac.uk/pdbsum/1yok PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yok RCSB]</span>
+
-
}}
+
'''crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol'''
'''crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol'''
Line 44: Line 41:
[[Category: Willson, T M.]]
[[Category: Willson, T M.]]
[[Category: Xu, R X.]]
[[Category: Xu, R X.]]
-
[[Category: lrh-1]]
+
[[Category: Lrh-1]]
-
[[Category: phosphatidylglycerol]]
+
[[Category: Phosphatidylglycerol]]
-
[[Category: tif-1]]
+
[[Category: Tif-1]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:35:11 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:15:45 2008''
+

Revision as of 13:35, 3 May 2008

Image:1yok.gif

Template:STRUCTURE 1yok

crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol


Overview

Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors.

About this Structure

1YOK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1., Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA, Cell. 2005 Feb 11;120(3):343-55. PMID:15707893 Page seeded by OCA on Sat May 3 16:35:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yok"
Personal tools