4lhr

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==Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensis==
==Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensis==
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<StructureSection load='4lhr' size='340' side='right' caption='[[4lhr]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4lhr' size='340' side='right'caption='[[4lhr]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lhr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burta Burta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LHR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_thailandensis_E264 Burkholderia thailandensis E264]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LHR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BTH_I0767, dut ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271848 BURTA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhr OCA], [https://pdbe.org/4lhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lhr RCSB], [https://www.ebi.ac.uk/pdbsum/4lhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhr ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhr OCA], [http://pdbe.org/4lhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lhr RCSB], [http://www.ebi.ac.uk/pdbsum/4lhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DUT_BURTA DUT_BURTA]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity).
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[https://www.uniprot.org/uniprot/DUT_BURTA DUT_BURTA] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity).
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==See Also==
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*[[DUTPase 3D structures|DUTPase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Burta]]
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[[Category: Burkholderia thailandensis E264]]
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[[Category: DUTP diphosphatase]]
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[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Hydrolase]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Nucleotide metabolism]]
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[[Category: Pyrimidine]]
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[[Category: Ssgcid]]
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Revision as of 11:02, 14 December 2022

Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensis

PDB ID 4lhr

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