Uridine 5'-monophosphate synthase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP [[2qcd]]' scene='52/526172/Cv/1' pspeed='8'> |
== Function == | == Function == | ||
| - | '''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP)<ref>PMID:8631878</ref>. UMPS N-terminal domain is an '''orotate phosphoribosyltransferase''' (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is '''orotidine 5’-phosphate decarboxylase''' (OPD) which decarboxylates OMP to form UMP. A potent inhibitor of OPD is BMP – a barbituric acid derivative. | + | '''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP)<ref>PMID:8631878</ref>. UMPS N-terminal domain is an '''orotate phosphoribosyltransferase''' (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is '''orotidine 5’-phosphate decarboxylase''' (OPD) or '''OMP decarboxylase''' which decarboxylates OMP to form UMP. A potent inhibitor of OPD is BMP – a barbituric acid derivative. |
== Disease == | == Disease == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Uridine 5’-monophosphate synthase | + | *Uridine 5’-monophosphate synthase OMP decarboxylase subunit |
**[[3gdk]] - yOPD – yeast<br /> | **[[3gdk]] - yOPD – yeast<br /> | ||
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**[[4df0]] – TnOPD – ''Thermoproteus neutrophilus'' <br /> | **[[4df0]] – TnOPD – ''Thermoproteus neutrophilus'' <br /> | ||
**[[3ve9]] – MsOPD – ''Metallosphaera sedula'' <br /> | **[[3ve9]] – MsOPD – ''Metallosphaera sedula'' <br /> | ||
| + | **[[3qw3]] – LdOPD – ''Leishmania donovani'' <br /> | ||
| + | **[[2za2]] - PfOPD - ''Plasmodium falciparum''<br /> | ||
| + | **[[1l2u]] - OPD - ''Escherichia coli''<br /> | ||
*Uridine 5’-monophosphate synthase OPD subunit complex | *Uridine 5’-monophosphate synthase OPD subunit complex | ||
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**[[2v30]], [[2qcd]] - hOPD + UMP<br /> | **[[2v30]], [[2qcd]] - hOPD + UMP<br /> | ||
**[[3ewy]] - hOPD (mutant) + UMP<br /> | **[[3ewy]] - hOPD (mutant) + UMP<br /> | ||
| - | **[[3gdl]] - yOPD + UMP derivative<br /> | ||
| - | **[[1dqx]], [[3gdt]] - yOPD (mutant) + UMP derivative<br /> | ||
**[[2qcg]], [[2qch]], [[3bgg]], [[3bgj]], [[3bk0]], [[3g3d]], [[3g3m]], [[3ewz]], [[3ex2]], [[3ex3]], [[3ex4]], [[3dbp]], [[3l0k]], [[3l0n]], [[3mo7]], [[3mw7]] - hOPD + UMP derivative<br /> | **[[2qcg]], [[2qch]], [[3bgg]], [[3bgj]], [[3bk0]], [[3g3d]], [[3g3m]], [[3ewz]], [[3ex2]], [[3ex3]], [[3ex4]], [[3dbp]], [[3l0k]], [[3l0n]], [[3mo7]], [[3mw7]] - hOPD + UMP derivative<br /> | ||
**[[3bvj]] - hOPD + xanthosine 5’-monophosphate<br /> | **[[3bvj]] - hOPD + xanthosine 5’-monophosphate<br /> | ||
**[[2qcf]], [[2qcm]], [[2qcn]], [[3ewu]], [[3ewx]], [[3ex6]] - hOPD (mutant) + UMP derivative<br /> | **[[2qcf]], [[2qcm]], [[2qcn]], [[3ewu]], [[3ewx]], [[3ex6]] - hOPD (mutant) + UMP derivative<br /> | ||
| + | **[[2qcl]] - hOPD (mutant) + OMP<br /> | ||
**[[3mi2]], [[4hib]], [[4hkp]] - hOPD + inhibitor<br /> | **[[3mi2]], [[4hib]], [[4hkp]] - hOPD + inhibitor<br /> | ||
**[[3ex1]] - hOPD + UMP derivative + UMP<br /> | **[[3ex1]] - hOPD + UMP derivative + UMP<br /> | ||
**[[2qcl]] - yOPD (mutant) + OMP <br /> | **[[2qcl]] - yOPD (mutant) + OMP <br /> | ||
| + | **[[3gdl]] - yOPD + UMP derivative<br /> | ||
| + | **[[1dqx]], [[3gdt]] - yOPD (mutant) + UMP derivative<br /> | ||
**[[4lw7]] – MtOPD + BMP – ''Methanothermobacter thermautotrophicus''<br /> | **[[4lw7]] – MtOPD + BMP – ''Methanothermobacter thermautotrophicus''<br /> | ||
**[[4lc6]], [[4lc8]], [[4fx8]], [[4gc4]], [[4fx6]], [[4fxr]], [[3v1p]] – MtOPD (mutant) + BMP <br /> | **[[4lc6]], [[4lc8]], [[4fx8]], [[4gc4]], [[4fx6]], [[4fxr]], [[3v1p]] – MtOPD (mutant) + BMP <br /> | ||
**[[4o8r]], [[4o11]], [[4nx5]], [[4nt0]], [[4nuw]], [[3wjw]], [[3wjx]], [[3wjy]], [[3wjz]], [[3w07]] - MtOPD + UMP derivative<br /> | **[[4o8r]], [[4o11]], [[4nx5]], [[4nt0]], [[4nuw]], [[3wjw]], [[3wjx]], [[3wjy]], [[3wjz]], [[3w07]] - MtOPD + UMP derivative<br /> | ||
| + | **[[1km1]], [[1kly]], [[1klz]], [[1km0]] - MtOPD (mutant) + UMP derivative<br /> | ||
**[[3wk0]], [[3wk1]], [[3wk2]], [[3wk3]] - MtOPD + OMP derivative<br /> | **[[3wk0]], [[3wk1]], [[3wk2]], [[3wk3]] - MtOPD + OMP derivative<br /> | ||
| + | **[[1km6]] - MtOPD (mutant) + OMP <br /> | ||
| + | **[[1lol]] - MtOPD + XMP <br /> | ||
**[[4muz]] – AfOPD + BMP <br /> | **[[4muz]] – AfOPD + BMP <br /> | ||
**[[4luj]] – MjOPD + BMP <br /> | **[[4luj]] – MjOPD + BMP <br /> | ||
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**[[4dbe]] – SsOPD + BMP <br /> | **[[4dbe]] – SsOPD + BMP <br /> | ||
**[[3ve7]] – MsOPD + BMP <br /> | **[[3ve7]] – MsOPD + BMP <br /> | ||
| - | + | **[[3vi2]] - PfOPD + inhibitor<br /> | |
| + | **[[2za1]] - PfOPD + OMP <br /> | ||
| + | **[[2za3]] - PfOPD + UMP <br /> | ||
| + | **[[1lp6]] - ArOPD + CMP - ''Archaea''<br /> | ||
| + | **[[1loq]] - ArOPD + UMP <br /> | ||
*Uridine 5’-monophosphate synthase OPRT subunit see orotate phosphoribosyltransferase in [[Phosphoribosyltransferase]] | *Uridine 5’-monophosphate synthase OPRT subunit see orotate phosphoribosyltransferase in [[Phosphoribosyltransferase]] | ||
Revision as of 23:01, 4 October 2018
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3D structures of uridine 5'-monophosphate synthase
Updated on 04-October-2018
References
- ↑ Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW. Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase. J Biol Chem. 1996 May 3;271(18):10704-8. PMID:8631878
- ↑ Grohmann K, Lauffer H, Lauenstein P, Hoffmann GF, Seidlitz G. Hereditary orotic aciduria with epilepsy and without megaloblastic anemia. Neuropediatrics. 2015 Apr;46(2):123-5. doi: 10.1055/s-0035-1547341. Epub 2015 Mar, 10. PMID:25757096 doi:http://dx.doi.org/10.1055/s-0035-1547341
- ↑ Schwenger B, Schober S, Simon D. DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene. Genomics. 1993 Apr;16(1):241-4. PMID:8486364 doi:http://dx.doi.org/10.1006/geno.1993.1165
- ↑ Wittmann JG, Heinrich D, Gasow K, Frey A, Diederichsen U, Rudolph MG. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure. 2008 Jan;16(1):82-92. PMID:18184586 doi:http://dx.doi.org/10.1016/j.str.2007.10.020
