Transketolase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='E. coli transketolase 1 dimer complex with xylulose-5-phosphate-thiamine diphosphate adduct, ethylene glycol and Ca+2 ion (green) (PDB code [[2r8o]]).' scene='46/466534/Cv/1'> |
== Function == | == Function == | ||
'''Transketolase''' (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle<ref>PMID:8369276</ref>. | '''Transketolase''' (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle<ref>PMID:8369276</ref>. | ||
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**[[4c7v]] - LsTKT – ''Lactobacillus salivarius''<br /> | **[[4c7v]] - LsTKT – ''Lactobacillus salivarius''<br /> | ||
**[[4xeu]] - TKT – ''Pseudomonas aeruginosa''<br /> | **[[4xeu]] - TKT – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[5i4i]] - PsTKT – ''Pichia stipitis''<br /> | + | **[[5i4i]], [[5xry]] - PsTKT – ''Pichia stipitis''<br /> |
**[[5hgx]], [[5i5g]] - PsTKT (mutant)<br /> | **[[5hgx]], [[5i5g]] - PsTKT (mutant)<br /> | ||
**[[5nd6]] - CrTKT – ''Chlamydomonas reinhardtii''<br /> | **[[5nd6]] - CrTKT – ''Chlamydomonas reinhardtii''<br /> | ||
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**[[1r9j]] - TKT + TPP – ''Leishmania mexicana''<br /> | **[[1r9j]] - TKT + TPP – ''Leishmania mexicana''<br /> | ||
**[[4c7x]] - LsTKT + TPP <br /> | **[[4c7x]] - LsTKT + TPP <br /> | ||
| - | **[[5hyv]] - PsTKT + TPP <br /> | + | **[[5hyv]], [[5x56]], [[5xuf]], [[5xvt]] - PsTKT + TPP <br /> |
| + | **[[5xsa]], [[5xsb]], [[5xsm]], [[5xt0]], [[5xt4]], [[5xtv]], [[5xtx]] - PsTKT + TPP intermediate<br /> | ||
| + | **[[5xtl]] - PsTKT + pyrimidine derivative <br /> | ||
**[[5nd5]] - CrTKT + TPP <br /> | **[[5nd5]] - CrTKT + TPP <br /> | ||
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**[[2r5n]] – EcTKT 1 + TPP + ribose 5-P<br /> | **[[2r5n]] – EcTKT 1 + TPP + ribose 5-P<br /> | ||
| - | **[[3upt]] - BtTKT + TPP + ribose 5-P<br /> | + | **[[3upt]],[[5xqa]] - BtTKT + TPP + ribose 5-P<br /> |
| - | **[[2r8o]] - EcTKT 1 + TPP + xylulose 5-P | + | **[[2r8o]], [[5xqk]] - EcTKT 1 + TPP + xylulose 5-P |
**[[2r8p]] - EcTKT 1 + TPP + fructose 6-P<br /> | **[[2r8p]] - EcTKT 1 + TPP + fructose 6-P<br /> | ||
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**[[4kxx]] - hTKT + TPP + seduheptulose 7-P<br /> | **[[4kxx]] - hTKT + TPP + seduheptulose 7-P<br /> | ||
**[[5hje]] - PsTKT + TPP + seduheptulose 7-P<br /> | **[[5hje]] - PsTKT + TPP + seduheptulose 7-P<br /> | ||
| - | **[[5i51]] - PsTKT + TPP + fructose 6-P<br /> | + | **[[5i51]], [[5xrv]], [[5xu2]] - PsTKT + TPP + fructose 6-P<br /> |
| + | **[[5xps]], [[5xu9]] - PsTKT + TPP + erythrose 4-P<br /> | ||
**[[5i5e]] - PsTKT (mutant) + TPP + xylulose 5-P<br /> | **[[5i5e]] - PsTKT (mutant) + TPP + xylulose 5-P<br /> | ||
}} | }} | ||
Revision as of 22:43, 26 September 2018
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3D Structures of transketolase
Updated on 26-September-2018
References
- ↑ Verschueren KH, Kingma J, Rozeboom HJ, Kalk KH, Janssen DB, Dijkstra BW. Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Biochemistry. 1993 Sep 7;32(35):9031-7. PMID:8369276
- ↑ Asztalos P, Parthier C, Golbik R, Kleinschmidt M, Hubner G, Weiss MS, Friedemann R, Wille G, Tittmann K. Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate. Biochemistry. 2007 Oct 30;46(43):12037-52. Epub 2007 Oct 3. PMID:17914867 doi:10.1021/bi700844m
