Transcription initiation factor

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<StructureSection load='' size='400' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>
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<StructureSection load='' size='350' side='right' caption='Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry [[1vol]])' scene='51/517377/Cv/1' pspeed='8'>
'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />
'''Transcription initiation factors''' (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process<ref>PMID:8870495</ref><ref>PMID:10022900</ref>.<br />
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**[[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br />
**[[1ytf]], [[1nh2]], [[1rm1]] – yTFIIA + TBP + DNA – yeast<br />
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**[[5fur]] – yTFIIA + yTFIIF + TATA-binding protein + DNA - CryoEM<br />
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**[[5m4s]] – hTFIIA – human<br />
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**[[1nvp]] – hTFIIA + TATA-binding protein + DNA – human<br />
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**[[1nvp]] – hTFIIA + TATA-binding protein + DNA <br />
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**[[5fur]] – hTFIIA + hTFIIF + TATA-binding protein + DNA - CryoEM<br />
*TFIIB
*TFIIB
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**[[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB <br />
**[[3k1f]], [[3k7a]], [[4bbr]], [[4bbs]] – yTFIIB <br />
**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM<br />
**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM<br />
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**[[5fmf]] – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM<br />
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**[[5fmf]], [[5sva]], [[5oqj]], [[5oqm]] – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM<br />
*TF RRN3
*TF RRN3

Revision as of 19:18, 26 September 2018

Structure of human TFIIB (cyan) complex with TATA-binding protein (green) and DNA (PDB entry 1vol)

Drag the structure with the mouse to rotate

3D structures of transcription initiation factors

Updated on 26-September-2018

References

  1. ↑ Roeder RG. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci. 1996 Sep;21(9):327-35. PMID:8870495
  2. ↑ Kuhlman TC, Cho H, Reinberg D, Hernandez N. The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter. Mol Cell Biol. 1999 Mar;19(3):2130-41. PMID:10022900
  3. ↑ Ha I, Lane WS, Reinberg D. Cloning of a human gene encoding the general transcription initiation factor IIB. Nature. 1991 Aug 22;352(6337):689-95. PMID:1876184 doi:http://dx.doi.org/10.1038/352689a0
  4. ↑ Peterson MG, Inostroza J, Maxon ME, Flores O, Admon A, Reinberg D, Tjian R. Structure and functional properties of human general transcription factor IIE. Nature. 1991 Dec 5;354(6352):369-73. PMID:1956398 doi:http://dx.doi.org/10.1038/354369a0
  5. ↑ Yamamoto RT, Nogi Y, Dodd JA, Nomura M. RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template. EMBO J. 1996 Aug 1;15(15):3964-73. PMID:8670901

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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