TNF receptor-associated factor
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code [[1f3v]])' scene='70/708054/Cv/1'> |
== Function == | == Function == | ||
'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>. '''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs. '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK. '''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>. '''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>. | '''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>. '''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs. '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK. '''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>. '''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>. | ||
| Line 14: | Line 14: | ||
*TRAF1 | *TRAF1 | ||
| - | **[[5e1t]] – | + | **[[5e1t]] – hTRAF1 TRAF domain - human<br /> |
**[[3m0d]] – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 <br /> | **[[3m0d]] – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 <br /> | ||
| + | **[[5h10]] – hTRAF1 TRAF domain + TANK peptide <br /> | ||
*TRAF2 | *TRAF2 | ||
| - | **[[1ca4]] – hTRAF2 TRAF domain | + | **[[1ca4]] – hTRAF2 TRAF domain<br /> |
| - | **[[3knv]] – hTRAF2 RING+zinc finger 1 domains | + | **[[3knv]] – hTRAF2 RING+zinc finger 1 domains <br /> |
**[[3m06]] – hTRAF2 residues 266-329 <br /> | **[[3m06]] – hTRAF2 residues 266-329 <br /> | ||
| Line 36: | Line 37: | ||
*TRAF3 | *TRAF3 | ||
| - | **[[4ghu]] – TRAF3 TRAF domain | + | **[[4ghu]] – TRAF3 TRAF domain + antiviral-signaling protein peptide - mouse <br /> |
*TRAF4 | *TRAF4 | ||
| - | **[[4k8u]], [[3zjb]], [[4m4e]] – hTRAF4 TRAF domain | + | **[[4k8u]], [[3zjb]], [[4m4e]] – hTRAF4 TRAF domain <br /> |
| + | **[[5yc1]] – hTRAF4 TRAF domain + GLIB peptide <br /> | ||
*TRAF5 | *TRAF5 | ||
| - | **[[4gjh]] – hTRAF5 TRAF domain | + | **[[4gjh]] – hTRAF5 TRAF domain <br /> |
| - | *TRAF6 | + | *TRAF6; domains: RING 50-124; zinc finger 1 125-159;zinc fingers 2,3 160-211; TRAF 346-504 |
**[[1lb4]] – hTRAF6 TRAF domain <br /> | **[[1lb4]] – hTRAF6 TRAF domain <br /> | ||
| Line 58: | Line 60: | ||
**[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br /> | **[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br /> | ||
**[[4z8m]] – hTRAF6 TRAF domain + antiviral-signaling protein peptide<br /> | **[[4z8m]] – hTRAF6 TRAF domain + antiviral-signaling protein peptide<br /> | ||
| + | **[[5vnz]], [[5vo0]] – TRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2 - zebrafish<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 16:27, 26 September 2018
| |||||||||||
3D Structures of TNF receptor-associated factor
Updated on 26-September-2018
References
- ↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:http://dx.doi.org/10.1038/sj.onc.1204788
- ↑ Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x. PMID:22017431 doi:http://dx.doi.org/10.1111/j.1600-065X.2011.01055.x
- ↑ Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. PMID:20946164 doi:http://dx.doi.org/10.1111/j.1538-7836.2010.04091.x
- ↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748
