1yrk

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[[Image:1yrk.gif|left|200px]]
[[Image:1yrk.gif|left|200px]]
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{{Structure
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|PDB= 1yrk |SIZE=350|CAPTION= <scene name='initialview01'>1yrk</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1yrk", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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{{STRUCTURE_1yrk| PDB=1yrk | SCENE= }}
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|RELATEDENTRY=[[1bdy|1BDY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrk OCA], [http://www.ebi.ac.uk/pdbsum/1yrk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yrk RCSB]</span>
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'''The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain'''
'''The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain'''
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[[Category: Soltoff, S P.]]
[[Category: Soltoff, S P.]]
[[Category: Wu, N.]]
[[Category: Wu, N.]]
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[[Category: c2 domain]]
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[[Category: C2 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:41:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:19:20 2008''
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Revision as of 13:41, 3 May 2008

Image:1yrk.gif

Template:STRUCTURE 1yrk

The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain


Overview

In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.

About this Structure

1YRK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:15851022 Page seeded by OCA on Sat May 3 16:41:35 2008

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