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2f1n

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==Structure of CdtB, the biologically active subunit of Cytolethal Distending Toxin==
==Structure of CdtB, the biologically active subunit of Cytolethal Distending Toxin==
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<StructureSection load='2f1n' size='340' side='right' caption='[[2f1n]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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<StructureSection load='2f1n' size='340' side='right'caption='[[2f1n]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2f1n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F1N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2f1n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F1N FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdtB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f1n OCA], [http://pdbe.org/2f1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f1n RCSB], [http://www.ebi.ac.uk/pdbsum/2f1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f1n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f1n OCA], [https://pdbe.org/2f1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f1n RCSB], [https://www.ebi.ac.uk/pdbsum/2f1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f1n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CDTB_ECOLX CDTB_ECOLX]] Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.<ref>PMID:11292766</ref>
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[[https://www.uniprot.org/uniprot/CDTB_ECOLX CDTB_ECOLX]] Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.<ref>PMID:11292766</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f1n_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f1n_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Bacillus coli migula 1895]]
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[[Category: Large Structures]]
[[Category: Dreyfus, L A]]
[[Category: Dreyfus, L A]]
[[Category: Hontz, J S]]
[[Category: Hontz, J S]]

Revision as of 12:37, 10 February 2021

Structure of CdtB, the biologically active subunit of Cytolethal Distending Toxin

PDB ID 2f1n

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