1yt9

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[[Image:1yt9.jpg|left|200px]]
[[Image:1yt9.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1yt9 |SIZE=350|CAPTION= <scene name='initialview01'>1yt9</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1yt9", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=OIS:(S)-N-((2S,3R)-3-HYDROXY-4-(4-((E)-(HYDROXYIMINO)METHYL)-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YL)-3-METHYL-2-(3-((2-METHYLTHIAZOL-4-YL)METHYL)-2-OXOIMIDAZOLIDIN-1-YL)BUTANAMIDE'>OIS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_1yt9| PDB=1yt9 | SCENE= }}
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|RELATEDENTRY=[[1mui|1MUI]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yt9 OCA], [http://www.ebi.ac.uk/pdbsum/1yt9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yt9 RCSB]</span>
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}}
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'''HIV Protease with oximinoarylsulfonamide bound'''
'''HIV Protease with oximinoarylsulfonamide bound'''
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[[Category: Yeung, C M.]]
[[Category: Yeung, C M.]]
[[Category: Zhao, C.]]
[[Category: Zhao, C.]]
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[[Category: hiv protease]]
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[[Category: Hiv protease]]
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[[Category: oximinoarylsulfonamide]]
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[[Category: Oximinoarylsulfonamide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:45:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:21:18 2008''
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Revision as of 13:45, 3 May 2008

Image:1yt9.jpg

Template:STRUCTURE 1yt9

HIV Protease with oximinoarylsulfonamide bound


Overview

The need for a potent HIV protease inhibitor (PI) to combat emerging PI-resistant viruses is anticipated. Analogs formulated from the combination of structural fragments of Ritonavir, Lopinavir, and Amprenavir were synthesized. Analogs containing the oxime pharmacophore were found to have improved activities against both wild type and resistant (A17) viruses. The synthesis and structure-activity relationships (SAR) based upon the in vitro IC50 of this series of compounds are reported.

About this Structure

1YT9 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Oximinoarylsulfonamides as potent HIV protease inhibitors., Yeung CM, Klein LL, Flentge CA, Randolph JT, Zhao C, Sun M, Dekhtyar T, Stoll VS, Kempf DJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2275-8. PMID:15837308 Page seeded by OCA on Sat May 3 16:45:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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