1ytb

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[[Image:1ytb.jpg|left|200px]]
[[Image:1ytb.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ytb", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1ytb| PDB=1ytb | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ytb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ytb OCA], [http://www.ebi.ac.uk/pdbsum/1ytb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ytb RCSB]</span>
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'''CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX'''
'''CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX'''
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[[Category: Kim, Y.]]
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[[Category: Sigler, P B.]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:39:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:21:25 2008''
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Revision as of 06:39, 24 April 2008

Image:1ytb.jpg

Template:STRUCTURE 1ytb

CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX


Overview

The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA.

About this Structure

1YTB is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1YTB with [TATA-Binding Protein]. Full crystallographic information is available from OCA.

Reference

Crystal structure of a yeast TBP/TATA-box complex., Kim Y, Geiger JH, Hahn S, Sigler PB, Nature. 1993 Oct 7;365(6446):512-20. PMID:8413604 Page seeded by OCA on Thu Apr 24 09:39:47 2008

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