1ytf
From Proteopedia
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[[Image:1ytf.jpg|left|200px]] | [[Image:1ytf.jpg|left|200px]] | ||
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'''YEAST TFIIA/TBP/DNA COMPLEX''' | '''YEAST TFIIA/TBP/DNA COMPLEX''' | ||
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[[Category: Sargent, D F.]] | [[Category: Sargent, D F.]] | ||
[[Category: Tan, S.]] | [[Category: Tan, S.]] | ||
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Revision as of 06:40, 24 April 2008
YEAST TFIIA/TBP/DNA COMPLEX
Overview
The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.
About this Structure
1YTF is a Protein complex structure of sequences from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1YTF with [TATA-Binding Protein]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a yeast TFIIA/TBP/DNA complex., Tan S, Hunziker Y, Sargent DF, Richmond TJ, Nature. 1996 May 9;381(6578):127-51. PMID:8610010 Page seeded by OCA on Thu Apr 24 09:40:28 2008