This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2gtt
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ||
==Crystal structure of the rabies virus nucleoprotein-RNA complex== | ==Crystal structure of the rabies virus nucleoprotein-RNA complex== | ||
| - | <StructureSection load='2gtt' size='340' side='right' caption='[[2gtt]], [[Resolution|resolution]] 3.49Å' scene=''> | + | <StructureSection load='2gtt' size='340' side='right'caption='[[2gtt]], [[Resolution|resolution]] 3.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gtt]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GTT FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gtt]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GTT FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gtt OCA], [http://pdbe.org/2gtt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gtt RCSB], [http://www.ebi.ac.uk/pdbsum/2gtt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gtt ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gtt OCA], [http://pdbe.org/2gtt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gtt RCSB], [http://www.ebi.ac.uk/pdbsum/2gtt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gtt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/NCAP_RABVE NCAP_RABVE]] Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). | [[http://www.uniprot.org/uniprot/NCAP_RABVE NCAP_RABVE]] Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). | ||
| Line 18: | Line 17: | ||
</div> | </div> | ||
<div class="pdbe-citations 2gtt" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2gtt" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Nucleoprotein|Nucleoprotein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rabies virus]] | [[Category: Rabies virus]] | ||
[[Category: Albertini, A A.V]] | [[Category: Albertini, A A.V]] | ||
Revision as of 09:32, 24 July 2019
Crystal structure of the rabies virus nucleoprotein-RNA complex
| |||||||||||
