2h9b

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==Crystal structure of the effector binding domain of a BenM variant (BenM R156H/T157S)==
==Crystal structure of the effector binding domain of a BenM variant (BenM R156H/T157S)==
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<StructureSection load='2h9b' size='340' side='right' caption='[[2h9b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='2h9b' size='340' side='right'caption='[[2h9b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2h9b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciad Aciad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H9B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2h9b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aciad Aciad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H9B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f6p|2f6p]], [[2f7a|2f7a]], [[2f78|2f78]], [[2f97|2f97]], [[2f8d|2f8d]], [[2h98|2h98]], [[2h99|2h99]], [[2h9q|2h9q]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f6p|2f6p]], [[2f7a|2f7a]], [[2f78|2f78]], [[2f97|2f97]], [[2f8d|2f8d]], [[2h98|2h98]], [[2h99|2h99]], [[2h9q|2h9q]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">benM, benR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=62977 ACIAD])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">benM, benR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=62977 ACIAD])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h9b OCA], [http://pdbe.org/2h9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h9b RCSB], [http://www.ebi.ac.uk/pdbsum/2h9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2h9b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h9b OCA], [https://pdbe.org/2h9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h9b RCSB], [https://www.ebi.ac.uk/pdbsum/2h9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h9b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BENM_ACIAD BENM_ACIAD]] Positive regulator of the ben and cat genes for benzoate degradation. BenM is necessary for ben gene expression but not for expression of the cat genes, which can be regulated by CatM. Binds to the inducers cis,cis-muconate and benzoate.
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[[https://www.uniprot.org/uniprot/BENM_ACIAD BENM_ACIAD]] Positive regulator of the ben and cat genes for benzoate degradation. BenM is necessary for ben gene expression but not for expression of the cat genes, which can be regulated by CatM. Binds to the inducers cis,cis-muconate and benzoate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/2h9b_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/2h9b_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2h9b" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2h9b" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Aciad]]
[[Category: Aciad]]
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[[Category: Large Structures]]
[[Category: Craven, S H]]
[[Category: Craven, S H]]
[[Category: Ezezika, O C]]
[[Category: Ezezika, O C]]

Revision as of 07:34, 17 March 2021

Crystal structure of the effector binding domain of a BenM variant (BenM R156H/T157S)

PDB ID 2h9b

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