1yub

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[[Image:1yub.jpg|left|200px]]
[[Image:1yub.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1yub |SIZE=350|CAPTION= <scene name='initialview01'>1yub</scene>
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The line below this paragraph, containing "STRUCTURE_1yub", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_(adenine-N(6)-)-methyltransferase rRNA (adenine-N(6)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.48 2.1.1.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ERM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
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|DOMAIN=
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{{STRUCTURE_1yub| PDB=1yub | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yub OCA], [http://www.ebi.ac.uk/pdbsum/1yub PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yub RCSB]</span>
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'''SOLUTION STRUCTURE OF AN RRNA METHYLTRANSFERASE (ERMAM) THAT CONFERS MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN ANTIBIOTIC RESISTANCE, NMR, MINIMIZED AVERAGE STRUCTURE'''
'''SOLUTION STRUCTURE OF AN RRNA METHYLTRANSFERASE (ERMAM) THAT CONFERS MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN ANTIBIOTIC RESISTANCE, NMR, MINIMIZED AVERAGE STRUCTURE'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: rRNA (adenine-N(6)-)-methyltransferase]]
 
[[Category: Fesik, S W.]]
[[Category: Fesik, S W.]]
[[Category: Holzman, T F.]]
[[Category: Holzman, T F.]]
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[[Category: Yu, L.]]
[[Category: Yu, L.]]
[[Category: Zhong, P.]]
[[Category: Zhong, P.]]
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[[Category: erm]]
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[[Category: Erm]]
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[[Category: ermam]]
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[[Category: Ermam]]
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[[Category: methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: mls antibiotic]]
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[[Category: Mls antibiotic]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: rrna]]
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[[Category: Rrna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:47:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:22:43 2008''
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Revision as of 13:47, 3 May 2008

Image:1yub.jpg

Template:STRUCTURE 1yub

SOLUTION STRUCTURE OF AN RRNA METHYLTRANSFERASE (ERMAM) THAT CONFERS MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN ANTIBIOTIC RESISTANCE, NMR, MINIMIZED AVERAGE STRUCTURE


Overview

The Erm family of methyltransferases is responsible for the development of resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics. These enzymes methylate an adenine of 23S ribosomal RNA that prevents the MLS antibiotics from binding to the ribosome and exhibiting their antibacterial activity. Here we describe the three-dimensional structure of an Erm family member, ErmAM, as determined by NMR spectroscopy. The catalytic domain of ErmAM is structurally similar to that found in other methyltransferases and consists of a seven-stranded beta-sheet flanked by alpha-helices and a small two-stranded beta-sheet. In contrast to the catalytic domain, the substrate binding domain is different from other methyltransferases and adopts a novel fold that consists of four alpha-helices.

About this Structure

1YUB is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance., Yu L, Petros AM, Schnuchel A, Zhong P, Severin JM, Walter K, Holzman TF, Fesik SW, Nat Struct Biol. 1997 Jun;4(6):483-9. PMID:9187657 Page seeded by OCA on Sat May 3 16:47:53 2008

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