1yvf

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[[Image:1yvf.gif|left|200px]]
[[Image:1yvf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1yvf |SIZE=350|CAPTION= <scene name='initialview01'>1yvf</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_1yvf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PH7:(2Z)-2-(BENZOYLAMINO)-3-[4-(2-BROMOPHENOXY)PHENYL]-2-PROPENOIC+ACID'>PH7</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1yvf| PDB=1yvf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvf OCA], [http://www.ebi.ac.uk/pdbsum/1yvf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yvf RCSB]</span>
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}}
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'''Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145'''
'''Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145'''
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==About this Structure==
==About this Structure==
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1YVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVF OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVF OCA].
==Reference==
==Reference==
Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid., Pfefferkorn JA, Greene ML, Nugent RA, Gross RJ, Mitchell MA, Finzel BC, Harris MS, Wells PA, Shelly JA, Anstadt RA, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 May 16;15(10):2481-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15863301 15863301]
Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid., Pfefferkorn JA, Greene ML, Nugent RA, Gross RJ, Mitchell MA, Finzel BC, Harris MS, Wells PA, Shelly JA, Anstadt RA, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 May 16;15(10):2481-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15863301 15863301]
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[[Category: Hepatitis c virus]]
 
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[[Category: Protein complex]]
 
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Anstadt, R A.]]
[[Category: Anstadt, R A.]]
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[[Category: Shelly, J A.]]
[[Category: Shelly, J A.]]
[[Category: Wells, P A.]]
[[Category: Wells, P A.]]
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[[Category: finger]]
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[[Category: Finger]]
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[[Category: hcv]]
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[[Category: Hcv]]
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[[Category: ns5b]]
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[[Category: Ns5b]]
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[[Category: palm]]
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[[Category: Palm]]
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[[Category: polymerase]]
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[[Category: Polymerase]]
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[[Category: thumb]]
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[[Category: Thumb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:23:57 2008''
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Revision as of 13:50, 3 May 2008

Image:1yvf.gif

Template:STRUCTURE 1yvf

Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145


Overview

A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.

About this Structure

Full crystallographic information is available from OCA.

Reference

Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid., Pfefferkorn JA, Greene ML, Nugent RA, Gross RJ, Mitchell MA, Finzel BC, Harris MS, Wells PA, Shelly JA, Anstadt RA, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 May 16;15(10):2481-6. PMID:15863301 Page seeded by OCA on Sat May 3 16:50:17 2008

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OCA

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