1yvl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1yvl.gif|left|200px]]
[[Image:1yvl.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1yvl |SIZE=350|CAPTION= <scene name='initialview01'>1yvl</scene>, resolution 3.0&Aring;
+
The line below this paragraph, containing "STRUCTURE_1yvl", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= STAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1yvl| PDB=1yvl | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvl OCA], [http://www.ebi.ac.uk/pdbsum/1yvl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yvl RCSB]</span>
+
-
}}
+
'''Structure of Unphosphorylated STAT1'''
'''Structure of Unphosphorylated STAT1'''
Line 38: Line 35:
[[Category: Sondermann, H.]]
[[Category: Sondermann, H.]]
[[Category: Wang, W.]]
[[Category: Wang, W.]]
-
[[Category: signaling protein]]
+
[[Category: Signaling protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:50:42 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:24:13 2008''
+

Revision as of 13:50, 3 May 2008

Image:1yvl.gif

Template:STRUCTURE 1yvl

Structure of Unphosphorylated STAT1


Contents

Overview

The crystal structure has been determined at 3.0 A resolution for an unphosphorylated STAT1 (1-683) complexed with a phosphopeptide derived from the alpha chain of interferon gamma (IFNgamma) receptor. Two dimer interfaces are seen, one between the N domains (NDs) (amino acid residues 1-123) and the other between the core fragments (CFs) (residues 132-683). Analyses of the wild-type (wt) and mutant STAT1 proteins by static light scattering, analytical ultracentrifugation, and coimmunoprecipitation suggest that STAT1 is predominantly dimeric prior to activation, and the dimer is mediated by the ND interactions. The connecting region between the ND and the CF is flexible and allows two interconvertable orientations of the CFs, termed "antiparallel" or "parallel," as determined by SH2 domain orientations. Functional implications of these dimer conformations are discussed. Also revealed in this structure is the detailed interaction between STAT1 SH2 domain and its docking site on IFNgamma receptor.

Disease

Known disease associated with this structure: Mycobacterial infection, atypical, familial disseminated OMIM:[600555], STAT1 deficiency, complete OMIM:[600555]

About this Structure

1YVL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural bases of unphosphorylated STAT1 association and receptor binding., Mao X, Ren Z, Parker GN, Sondermann H, Pastorello MA, Wang W, McMurray JS, Demeler B, Darnell JE Jr, Chen X, Mol Cell. 2005 Mar 18;17(6):761-71. PMID:15780933 Page seeded by OCA on Sat May 3 16:50:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yvl"
Personal tools