1ywr

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[[Image:1ywr.gif|left|200px]]
[[Image:1ywr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ywr |SIZE=350|CAPTION= <scene name='initialview01'>1ywr</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1ywr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=LI9:4-(4-FLUOROPHENYL)-1-METHYL-5-(2-{[(1S)-1-PHENYLETHYL]AMINO}PYRIMIDIN-4-YL)-2-PIPERIDIN-4-YL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE'>LI9</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Mapk14, Crk1, Csbp1, Csbp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1ywr| PDB=1ywr | SCENE= }}
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|RELATEDENTRY=[[1yw2|1YW2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ywr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ywr OCA], [http://www.ebi.ac.uk/pdbsum/1ywr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ywr RCSB]</span>
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}}
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'''Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor'''
'''Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor'''
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[[Category: Walter, R L.]]
[[Category: Walter, R L.]]
[[Category: Webster, M E.]]
[[Category: Webster, M E.]]
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[[Category: moncyclic pyrazolone]]
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[[Category: Moncyclic pyrazolone]]
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[[Category: p38 kinase]]
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[[Category: P38 kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:53:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:25:24 2008''
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Revision as of 13:53, 3 May 2008

Image:1ywr.gif

Template:STRUCTURE 1ywr

Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor


Overview

4-Aryl-5-pyrimidyl based cytokine synthesis inhibitors that contain a novel monocyclic, pyrazolone heterocyclic core are described. Many of these inhibitors showed low nanomolar activity against LPS-induced TNF-alpha production. One of the compounds (6e) was found to be efficacious in the rat iodoacetate (RIA) in vivo model of osteoarthritis. The X-ray crystal structure of a pyrazolone inhibitor cocrystallized with mutated p38 (mp38) is presented.

About this Structure

1YWR is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The development of monocyclic pyrazolone based cytokine synthesis inhibitors., Golebiowski A, Townes JA, Laufersweiler MJ, Brugel TA, Clark MP, Clark CM, Djung JF, Laughlin SK, Sabat MP, Bookland RG, VanRens JC, De B, Hsieh LC, Janusz MJ, Walter RL, Webster ME, Mekel MJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2285-9. PMID:15837310 Page seeded by OCA on Sat May 3 16:53:45 2008

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OCA

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