1l2q

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(Difference between revisions)

Revision as of 09:07, 24 July 2019

Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)

Structural highlights

1l2q is a 1 chain structure with sequence from "methanosarcina_barkerii"_(sic)_schnellen_1947 "methanosarcina barkerii" (sic) schnellen 1947. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Related:	1l2r
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MTMB1_METBA] Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC (MtmC1 or MtmC2).^[1] ^[2]

Publication Abstract from PubMed

Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.

A new UAG-encoded residue in the structure of a methanogen methyltransferase.,Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK Science. 2002 May 24;296(5572):1462-6. PMID:12029132^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Burke SA, Lo SL, Krzycki JA. Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine. J Bacteriol. 1998 Jul;180(13):3432-40. PMID:9642198
↑ Burke SA, Krzycki JA. Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri. J Biol Chem. 1997 Jun 27;272(26):16570-7. PMID:9195968
↑ Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK. A new UAG-encoded residue in the structure of a methanogen methyltransferase. Science. 2002 May 24;296(5572):1462-6. PMID:12029132 doi:10.1126/science.1069556

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l2q"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)==
-<StructureSection load='1l2q' size='340' side='right' caption='[[1l2q]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+<StructureSection load='1l2q' size='340' side='right'caption='[[1l2q]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1l2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"methanosarcina_barkerii"_(sic)_schnellen_1947 "methanosarcina barkerii" (sic) schnellen 1947]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2Q FirstGlance]. <br>
@@ Line 22: / Line 22: @@
 ==See Also==
+*[[Monomethylamine methyltransferase|Monomethylamine methyltransferase]]
 *[[Pyrrolysine|Pyrrolysine]]
 == References ==
@@ Line 27: / Line 28: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Chan, M K]]
 [[Category: Ferguson, T K]]

1l2q

From Proteopedia

Revision as of 09:07, 24 July 2019

Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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