1z0s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1z0s.gif|left|200px]]
[[Image:1z0s.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1z0s |SIZE=350|CAPTION= <scene name='initialview01'>1z0s</scene>, resolution 1.7&Aring;
+
The line below this paragraph, containing "STRUCTURE_1z0s", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ppnK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0061 nadF]</span>
+
{{STRUCTURE_1z0s| PDB=1z0s | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0s OCA], [http://www.ebi.ac.uk/pdbsum/1z0s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z0s RCSB]</span>
+
-
}}
+
'''Crystal structure of an NAD kinase from Archaeoglobus fulgidus in complex with ATP'''
'''Crystal structure of an NAD kinase from Archaeoglobus fulgidus in complex with ATP'''
Line 24: Line 21:
Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP., Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH, J Mol Biol. 2005 Nov 25;354(2):289-303. Epub 2005 Sep 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16242716 16242716]
Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP., Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH, J Mol Biol. 2005 Nov 25;354(2):289-303. Epub 2005 Sep 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16242716 16242716]
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
-
[[Category: NAD(+) kinase]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Adams, P D.]]
[[Category: Adams, P D.]]
Line 33: Line 29:
[[Category: Lou, Y.]]
[[Category: Lou, Y.]]
[[Category: Yokota, H.]]
[[Category: Yokota, H.]]
-
[[Category: atp]]
+
[[Category: Atp]]
-
[[Category: atp-binding]]
+
[[Category: Atp-binding]]
-
[[Category: berkeley structural genomics center]]
+
[[Category: Berkeley structural genomics center]]
-
[[Category: bsgc]]
+
[[Category: Bsgc]]
-
[[Category: nad]]
+
[[Category: Nad]]
-
[[Category: nad kinase]]
+
[[Category: Nad kinase]]
-
[[Category: nadp]]
+
[[Category: Nadp]]
-
[[Category: protein structure initiative]]
+
[[Category: Protein structure initiative]]
-
[[Category: psi]]
+
[[Category: Psi]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:02:52 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:23 2008''
+

Revision as of 14:02, 3 May 2008

Image:1z0s.gif

Template:STRUCTURE 1z0s

Crystal structure of an NAD kinase from Archaeoglobus fulgidus in complex with ATP


Overview

NAD kinase is a ubiquitous enzyme that catalyzes the phosphorylation of NAD to NADP using ATP or inorganic polyphosphate (poly(P)) as phosphate donor, and is regarded as the only enzyme responsible for the synthesis of NADP. We present here the crystal structures of an NAD kinase from the archaeal organism Archaeoglobus fulgidus in complex with its phosphate donor ATP at 1.7 A resolution, with its substrate NAD at 3.05 A resolution, and with the product NADP in two different crystal forms at 2.45 A and 2.0 A resolution, respectively. In the ATP bound structure, the AMP portion of the ATP molecule is found to use the same binding site as the nicotinamide ribose portion of NAD/NADP in the NAD/NADP bound structures. A magnesium ion is found to be coordinated to the phosphate tail of ATP as well as to a pyrophosphate group. The conserved GGDG loop forms hydrogen bonds with the pyrophosphate group in the ATP-bound structure and the 2' phosphate group of the NADP in the NADP-bound structures. A possible phosphate transfer mechanism is proposed on the basis of the structures presented.

About this Structure

1Z0S is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP., Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH, J Mol Biol. 2005 Nov 25;354(2):289-303. Epub 2005 Sep 30. PMID:16242716 Page seeded by OCA on Sat May 3 17:02:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z0s"
Personal tools