Histidine triad nucleotide-binding protein

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== Relevance ==
== Relevance ==
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HINT is a tumor suppressor. FHIT-Ap(n)A complex functions in proapoptotic tumor suppression pathway. FHIT is overexpressed in inflammatory bowel disease<ref>PMID:20083852</ref> and in colorectal cancer<ref>PMID:20083853</ref>.
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HINT is a tumor suppressor. FHIT-Ap(n)A complex functions in proapoptotic tumor suppression pathway. FHIT is overexpressed in inflammatory bowel disease<ref>PMID:20083852</ref> and in colorectal cancer<ref>PMID:20083853</ref>.
== Structural highlights ==
== Structural highlights ==
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The <scene name='59/593304/Cv/4'>HINT nucleotide-binding cleft is at the top of the β sheet</scene><ref>PMID:9164465</ref>. Water molecules shown as red spheres.
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The <scene name='59/593304/Cv/5'>HINT nucleotide-binding cleft is at the top of the β sheet</scene><ref>PMID:9164465</ref>. Water molecules shown as red spheres.
</StructureSection>
</StructureSection>

Revision as of 12:43, 16 May 2019

Structure of rabbit HINT1 complex with GMP (PDB code 3rhn).

Drag the structure with the mouse to rotate

3D structures of histidine triad nucleotide-binding protein

Updated on 16-May-2019

References

  1. ↑ Linde CI, Feng B, Wang JB, Golovina VA. Histidine triad nucleotide-binding protein 1 (HINT1) regulates Ca(2+) signaling in mouse fibroblasts and neuronal cells via store-operated Ca(2+) entry pathway. Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1098-104. doi:, 10.1152/ajpcell.00073.2013. Epub 2013 Apr 10. PMID:23576580 doi:http://dx.doi.org/10.1152/ajpcell.00073.2013
  2. ↑ Wistuba II, Ashfaq R, Maitra A, Alvarez H, Riquelme E, Gazdar AF. Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma. Am J Pathol. 2002 Jun;160(6):2073-9. PMID:12057912 doi:http://dx.doi.org/10.1016/S0002-9440(10)61157-1
  3. ↑ Zochbauer-Muller S, Wistuba II, Minna JD, Gazdar AF. Fragile histidine triad (FHIT) gene abnormalities in lung cancer. Clin Lung Cancer. 2000 Nov;2(2):141-5. PMID:14731325
  4. ↑ Wierzbicki PM, Adrych K, Kartanowicz D, Wypych J, Stanislawowski M, Zwolinska-Wcislo M, Celinski K, Skrodzka D, Godlewski J, Korybalski B, Smoczynski M, Kmiec Z. Overexpression of the fragile histidine triad (FHIT) gene in inflammatory bowel disease. J Physiol Pharmacol. 2009 Oct;60 Suppl 4:57-62. PMID:20083852
  5. ↑ Wierzbicki PM, Adrych K, Kartanowicz D, Dobrowolski S, Stanislawowski M, Chybicki J, Godlewski J, Korybalski B, Smoczynski M, Kmiec Z. Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer. J Physiol Pharmacol. 2009 Oct;60 Suppl 4:63-70. PMID:20083853
  6. ↑ Brenner C, Garrison P, Gilmour J, Peisach D, Ringe D, Petsko GA, Lowenstein JM. Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins. Nat Struct Biol. 1997 Mar;4(3):231-8. PMID:9164465

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