1z1y

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[[Image:1z1y.gif|left|200px]]
[[Image:1z1y.gif|left|200px]]
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{{Structure
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|PDB= 1z1y |SIZE=350|CAPTION= <scene name='initialview01'>1z1y</scene>, resolution 2.000&Aring;
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The line below this paragraph, containing "STRUCTURE_1z1y", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1z1y| PDB=1z1y | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1y OCA], [http://www.ebi.ac.uk/pdbsum/1z1y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z1y RCSB]</span>
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}}
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'''Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax'''
'''Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax'''
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[[Category: Stowers, A W.]]
[[Category: Stowers, A W.]]
[[Category: Su, H P.]]
[[Category: Su, H P.]]
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[[Category: four egf-like domain]]
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[[Category: Four egf-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:05:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:52 2008''
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Revision as of 14:05, 3 May 2008

Image:1z1y.gif

Template:STRUCTURE 1z1y

Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax


Overview

P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.

About this Structure

1Z1Y is a Single protein structure of sequence from Plasmodium vivax. Full crystallographic information is available from OCA.

Reference

The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807 Page seeded by OCA on Sat May 3 17:05:18 2008

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OCA

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