5nj8
From Proteopedia
(Difference between revisions)
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==Structural basis for aryl hydrocarbon receptor mediated gene activation== | ==Structural basis for aryl hydrocarbon receptor mediated gene activation== | ||
| - | <StructureSection load='5nj8' size='340' side='right' caption='[[5nj8]], [[Resolution|resolution]] 3.30Å' scene=''> | + | <StructureSection load='5nj8' size='340' side='right'caption='[[5nj8]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5nj8]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJ8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5nj8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJ8 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ER3:ERBIUM+(III)+ION'>ER3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ER3:ERBIUM+(III)+ION'>ER3</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AHR, BHLHE76 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Arnt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nj8 OCA], [http://pdbe.org/5nj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nj8 RCSB], [http://www.ebi.ac.uk/pdbsum/5nj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nj8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nj8 OCA], [http://pdbe.org/5nj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nj8 RCSB], [http://www.ebi.ac.uk/pdbsum/5nj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nj8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/AHR_HUMAN AHR_HUMAN]] Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.<ref>PMID:10395741</ref> <ref>PMID:7961644</ref> [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/AHR_HUMAN AHR_HUMAN]] Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.<ref>PMID:10395741</ref> <ref>PMID:7961644</ref> [[http://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Daumke, O]] | [[Category: Daumke, O]] | ||
[[Category: Schulte, K W]] | [[Category: Schulte, K W]] | ||
[[Category: Basic helix loop helix pas domain transcription factor]] | [[Category: Basic helix loop helix pas domain transcription factor]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 08:57, 5 February 2020
Structural basis for aryl hydrocarbon receptor mediated gene activation
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