Netrin
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='4ove' size=' | + | <StructureSection load='4ove' size='350' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene='' pspeed='8'> |
== Function == | == Function == | ||
'''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | '''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | ||
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**[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | **[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | ||
**[[4urt]] – hNet1 LN-LE3 domains + hNet receptor DCC fourth fibronectin type V-VI domains - human<BR /> | **[[4urt]] – hNet1 LN-LE3 domains + hNet receptor DCC fourth fibronectin type V-VI domains - human<BR /> | ||
| + | **[[6fkq]] – hNet1 LN-LE3 domains + draxin peptide<BR /> | ||
*Netrin-4 | *Netrin-4 | ||
Revision as of 10:23, 12 August 2018
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3D Structures of netrin
Updated on 12-August-2018
References
- ↑ Moore SW, Tessier-Lavigne M, Kennedy TE. Netrins and their receptors. Adv Exp Med Biol. 2007;621:17-31. doi: 10.1007/978-0-387-76715-4_2. PMID:18269208 doi:http://dx.doi.org/10.1007/978-0-387-76715-4_2
- ↑ Ylivinkka I, Hu Y, Chen P, Rantanen V, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiainen M. Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion. J Cell Sci. 2013 Jun 1;126(Pt 11):2459-69. doi: 10.1242/jcs.120022. Epub 2013 Apr, 2. PMID:23549787 doi:http://dx.doi.org/10.1242/jcs.120022
- ↑ Layne K, Ferro A, Passacquale G. Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit? Cardiovasc Res. 2015 Sep 1;107(4):410-9. doi: 10.1093/cvr/cvv201. Epub 2015 Jul, 24. PMID:26209250 doi:http://dx.doi.org/10.1093/cvr/cvv201
