Neurexin

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== Structural highlights ==
== Structural highlights ==
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The <scene name='42/424006/Cv/5'>surface interaction between NRXN and neuroligin</scene> is mediated by a <scene name='42/424006/Cv/6'>Ca+2 ion</scene><ref>PMID:20543817</ref>. Water molecules shown as red spheres.
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The <scene name='42/424006/Cv/7'>surface interaction between NRXN and neuroligin</scene> is mediated by a <scene name='42/424006/Cv/8'>Ca+2 ion</scene><ref>PMID:20543817</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>

Revision as of 13:09, 22 July 2019

Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry 2xb6)

Drag the structure with the mouse to rotate

3D Structures of Neurexin

22-July-2019

References

  1. ↑ Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P. Neurexin mediates the assembly of presynaptic terminals. Nat Neurosci. 2003 Jul;6(7):708-16. PMID:12796785 doi:http://dx.doi.org/10.1038/nn1074
  2. ↑ Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y, Lally E, Weiss LA, Najm J, Kutsche K, Descartes M, Holt L, Braddock S, Troxell R, Kaplan L, Volkmar F, Klin A, Tsatsanis K, Harris DJ, Noens I, Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF. Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet. 2008 Jan;82(1):199-207. doi: 10.1016/j.ajhg.2007.09.011. PMID:18179900 doi:http://dx.doi.org/10.1016/j.ajhg.2007.09.011
  3. ↑ Leone P, Comoletti D, Ferracci G, Conrod S, Garcia SU, Taylor P, Bourne Y, Marchot P. Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J. 2010 Jul 21;29(14):2461-71. Epub 2010 Jun 11. PMID:20543817 doi:10.1038/emboj.2010.123
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