Prestin

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Pre C-terminal is mainly composed of a STAS (Sulfate Transporters and Anti-Sigma factor antagonist) domain<ref>PMID:20471983</ref>.
Pre C-terminal is mainly composed of a STAS (Sulfate Transporters and Anti-Sigma factor antagonist) domain<ref>PMID:20471983</ref>.
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*<scene name='72/725863/Cv/2'>1st Cl coordination site</scene>. Water molecules shown as red spheres.
+
*<scene name='72/725863/Cv/4'>1st Cl coordination site</scene>. Water molecules are shown as red spheres.
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*<scene name='72/725863/Cv/3'>2nd Cl coordination site</scene>.
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*<scene name='72/725863/Cv/5'>2nd Cl coordination site</scene>.
</StructureSection>
</StructureSection>

Revision as of 13:06, 14 August 2019

Rat prestin STAS domain complex with Cl- ion and ethylene glycol (PDB code 5euu)

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3D Structures of prestin

Updated on 14-August-2019

3llo – rPre STAS domain – rat
5eus – rPre STAS domain + Br
5euu – rPre STAS domain + Cl
5euz – rPre STAS domain + I
5euw – rPre STAS domain + NO3
5eux – rPre STAS domain + CNS
5ezb – Pre STAS domain - chicken

References

  1. ↑ Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P. Prestin is the motor protein of cochlear outer hair cells. Nature. 2000 May 11;405(6783):149-55. PMID:10821263 doi:http://dx.doi.org/10.1038/35012009
  2. ↑ Liu XZ, Ouyang XM, Xia XJ, Zheng J, Pandya A, Li F, Du LL, Welch KO, Petit C, Smith RJ, Webb BT, Yan D, Arnos KS, Corey D, Dallos P, Nance WE, Chen ZY. Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum Mol Genet. 2003 May 15;12(10):1155-62. PMID:12719379
  3. ↑ Pasqualetto E, Aiello R, Gesiot L, Bonetto G, Bellanda M, Battistutta R. Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26/SulP anion transporters. J Mol Biol. 2010 Jul 16;400(3):448-62. Epub 2010 May 21. PMID:20471983 doi:10.1016/j.jmb.2010.05.013

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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