1oax

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1oax.gif|left|200px]]<br />
+
[[Image:1oax.jpg|left|200px]]<br /><applet load="1oax" size="450" color="white" frame="true" align="right" spinBox="true"
-
<applet load="1oax" size="450" color="white" frame="true" align="right" spinBox="true"
+
caption="1oax, resolution 2.67&Aring;" />
caption="1oax, resolution 2.67&Aring;" />
'''FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH ACENAPHTHENEQUINONE'''<br />
'''FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH ACENAPHTHENEQUINONE'''<br />
Line 8: Line 7:
==About this Structure==
==About this Structure==
-
1OAX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus] with ANQ as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OAX OCA].
+
1OAX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus] with ANQ as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Anq Binding Site For Chain J'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OAX OCA].
==Reference==
==Reference==
Line 22: Line 21:
[[Category: ige]]
[[Category: ige]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 16:48:40 2007''
+
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 17:17:31 2007''

Revision as of 15:07, 18 December 2007

Image:1oax.jpg

1oax, resolution 2.67Å

Drag the structure with the mouse to rotate

FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH ACENAPHTHENEQUINONE

Overview

A single antibody was shown to adopt different binding-site conformations, and thereby bind unrelated antigens. Analysis by both x-ray, crystallography and pre-steady-state kinetics revealed an equilibrium, between different preexisting isomers, one of which possessed a, promiscuous, low-affinity binding site for aromatic ligands, including the, immunizing hapten. A subsequent induced-fit isomerization led to, high-affinity complexes with a deep and narrow binding site. A protein, antigen identified by repertoire selection made use of an unrelated, antibody isomer with a wide, shallow binding site. Conformational, diversity, whereby one sequence adopts multiple structures and multiple, functions, can increase the effective size of the antibody repertoire but, may also lead to autoimmunity and allergy.

About this Structure

1OAX is a Protein complex structure of sequences from Rattus rattus with ANQ as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298

Page seeded by OCA on Tue Dec 18 17:17:31 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oax"
Personal tools