1z58

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[[Image:1z58.gif|left|200px]]
[[Image:1z58.gif|left|200px]]
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{{Structure
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|PDB= 1z58 |SIZE=350|CAPTION= <scene name='initialview01'>1z58</scene>, resolution 3.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1z58", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1z58| PDB=1z58 | SCENE= }}
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|RELATEDENTRY=[[1ond|1ond]], [[1p9x|1p9x]], [[1nkw|1nkw]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z58 OCA], [http://www.ebi.ac.uk/pdbsum/1z58 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z58 RCSB]</span>
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'''Crystal structure of a complex of the ribosome large subunit with rapamycin'''
'''Crystal structure of a complex of the ribosome large subunit with rapamycin'''
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[[Category: Harms, J.]]
[[Category: Harms, J.]]
[[Category: Yonath, A.]]
[[Category: Yonath, A.]]
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[[Category: polyketyde]]
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[[Category: Polyketyde]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: tunnel]]
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[[Category: Tunnel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:14 2008''
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Revision as of 14:11, 3 May 2008

Image:1z58.gif

Template:STRUCTURE 1z58

Crystal structure of a complex of the ribosome large subunit with rapamycin


Overview

RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.

About this Structure

1Z58 is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

A crevice adjoining the ribosome tunnel: hints for cotranslational folding., Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A, FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:15943964 Page seeded by OCA on Sat May 3 17:11:22 2008

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