6apm

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'''Unreleased structure'''
 
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The entry 6apm is ON HOLD until Paper Publication
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==Hen egg-white lysozyme (WT), solved with serial millisecond crystallography using synchrotron radiation==
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<StructureSection load='6apm' size='340' side='right' caption='[[6apm]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6apm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6APM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6apk|6apk]], [[6apg|6apg]], [[6apf|6apf]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6apm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6apm OCA], [http://pdbe.org/6apm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6apm RCSB], [http://www.ebi.ac.uk/pdbsum/6apm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6apm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the trans-acyltransferase (AT) from the disorazole polyketide synthase (PKS) was determined at room temperature to a resolution of 2.5 A using a new method for the direct delivery of the sample into an X-ray free-electron laser. A novel sample extractor efficiently delivered limited quantities of microcrystals directly from the native crystallization solution into the X-ray beam at room temperature. The AT structure revealed important catalytic features of this core PKS enzyme, including the occurrence of conformational changes around the active site. The implications of these conformational changes for polyketide synthase reaction dynamics are discussed.
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Authors: Lyubimov, A.Y., Mathews, I.I., Uervivojnangkoorn, M., Soltis, S.M., Cohen, A.E.
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The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.,Mathews II, Allison K, Robbins T, Lyubimov AY, Uervirojnangkoorn M, Brunger AT, Khosla C, DeMirci H, McPhillips SE, Hollenbeck M, Soltis M, Cohen AE Biochemistry. 2017 Sep 12;56(36):4751-4756. doi: 10.1021/acs.biochem.7b00711., Epub 2017 Aug 31. PMID:28832129<ref>PMID:28832129</ref>
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Description: Hen egg-white lysozyme (WT), solved with serial millisecond crystallography using synchrotron radiation
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Cohen, A.E]]
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<div class="pdbe-citations 6apm" style="background-color:#fffaf0;"></div>
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[[Category: Lyubimov, A.Y]]
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== References ==
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[[Category: Soltis, S.M]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Lysozyme]]
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[[Category: Cohen, A E]]
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[[Category: Lyubimov, A Y]]
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[[Category: Mathews, I I]]
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[[Category: Soltis, S M]]
[[Category: Uervivojnangkoorn, M]]
[[Category: Uervivojnangkoorn, M]]
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[[Category: Mathews, I.I]]
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[[Category: Hewl]]
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[[Category: Hydrolase]]
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[[Category: Serial millisecond crystallography]]
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[[Category: Xfel crystal structure]]

Revision as of 05:57, 4 April 2018

Hen egg-white lysozyme (WT), solved with serial millisecond crystallography using synchrotron radiation

6apm, resolution 2.05Å

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