1z5l

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[[Image:1z5l.gif|left|200px]]
[[Image:1z5l.gif|left|200px]]
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{{Structure
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|PDB= 1z5l |SIZE=350|CAPTION= <scene name='initialview01'>1z5l</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1z5l", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene>
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{{STRUCTURE_1z5l| PDB=1z5l | SCENE= }}
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|RELATEDENTRY=[[1cd1|1CD1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5l OCA], [http://www.ebi.ac.uk/pdbsum/1z5l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z5l RCSB]</span>
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'''Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D'''
'''Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D'''
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[[Category: Zajonc, D M.]]
[[Category: Zajonc, D M.]]
[[Category: Zhou, D.]]
[[Category: Zhou, D.]]
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[[Category: ig fold]]
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[[Category: Ig fold]]
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[[Category: mhc fold]]
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[[Category: Mhc fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:23 2008''
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Revision as of 14:11, 3 May 2008

Image:1z5l.gif

Template:STRUCTURE 1z5l

Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D


Overview

Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the alpha-linkage as a unique pathogen-specific pattern-recognition motif. Comparison of the binding of altered lipid ligands to CD1d and T cell receptors suggested that the differential T helper type 1-like and T helper type 2-like properties of natural killer T cells may originate largely from differences in their 'loading' in different cell types and hence in their tissue distribution in vivo.

About this Structure

1Z5L is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor., Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L, Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 Page seeded by OCA on Sat May 3 17:11:55 2008

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