6ent
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the rat RKIP variant delta143-146== | |
| - | + | <StructureSection load='6ent' size='340' side='right' caption='[[6ent]], [[Resolution|resolution]] 2.66Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ent]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ENT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ENT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ens|6ens]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ent FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ent OCA], [http://pdbe.org/6ent PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ent RCSB], [http://www.ebi.ac.uk/pdbsum/6ent PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ent ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PEBP1_RAT PEBP1_RAT]] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hirschbeck, M]] | ||
| + | [[Category: Kisker, C]] | ||
| + | [[Category: Koelmel, W]] | ||
| + | [[Category: Lorenz, K]] | ||
| + | [[Category: Schindelin, H]] | ||
| + | [[Category: Pbp]] | ||
| + | [[Category: Pebp]] | ||
| + | [[Category: Rkip]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 07:05, 13 December 2017
Structure of the rat RKIP variant delta143-146
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Categories: Hirschbeck, M | Kisker, C | Koelmel, W | Lorenz, K | Schindelin, H | Pbp | Pebp | Rkip | Signaling protein
