6ero
From Proteopedia
(Difference between revisions)
m (Protected "6ero" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human TFB2M== | |
| - | + | <StructureSection load='6ero' size='340' side='right' caption='[[6ero]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ero]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ero FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ero OCA], [http://pdbe.org/6ero PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ero RCSB], [http://www.ebi.ac.uk/pdbsum/6ero PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ero ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/TFB2M_HUMAN TFB2M_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.<ref>PMID:12068295</ref> <ref>PMID:12897151</ref> <ref>PMID:15526033</ref> <ref>PMID:20410300</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Cramer, P]] | [[Category: Cramer, P]] | ||
| - | [[Category: Hillen, H | + | [[Category: Hillen, H S]] |
| + | [[Category: Morozov, Y I]] | ||
[[Category: Sarfallah, A]] | [[Category: Sarfallah, A]] | ||
| + | [[Category: Temiakov, D]] | ||
| + | [[Category: Initiation]] | ||
| + | [[Category: Mitochondria]] | ||
| + | [[Category: Polymerase]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 07:42, 15 November 2017
Structure of human TFB2M
| |||||||||||
