1z7h

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[[Image:1z7h.gif|left|200px]]
[[Image:1z7h.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1z7h |SIZE=350|CAPTION= <scene name='initialview01'>1z7h</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1z7h", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 Clostridium tetani])
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-->
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|DOMAIN=
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{{STRUCTURE_1z7h| PDB=1z7h | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7h OCA], [http://www.ebi.ac.uk/pdbsum/1z7h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z7h RCSB]</span>
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}}
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'''2.3 Angstrom crystal structure of tetanus neurotoxin light chain'''
'''2.3 Angstrom crystal structure of tetanus neurotoxin light chain'''
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[[Category: Breidenbach, M A.]]
[[Category: Breidenbach, M A.]]
[[Category: Brunger, A T.]]
[[Category: Brunger, A T.]]
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[[Category: metalloprotease]]
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[[Category: Metalloprotease]]
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[[Category: neurotransmission]]
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[[Category: Neurotransmission]]
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[[Category: snare]]
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[[Category: Snare]]
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[[Category: tent]]
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[[Category: Tent]]
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[[Category: tetanus]]
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[[Category: Tetanus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:16:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:31:00 2008''
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Revision as of 14:16, 3 May 2008

Image:1z7h.gif

Template:STRUCTURE 1z7h

2.3 Angstrom crystal structure of tetanus neurotoxin light chain


Overview

TeNT is the causative agent of the neuroparalytic disease tetanus. A key component of TeNT is its light chain, a Zn(2+) endopeptidase that targets SNAREs. Recent structural studies of closely related BoNT endopeptidases indicate that substrate-binding exosites remote from a conserved active site are the primary determinants of substrate specificity. Here we report the 2.3 A X-ray crystal structure of TeNT-LC, determined by combined molecular replacement and MAD phasing. As expected, the overall structure of TeNT-LC is similar to the other known CNT light chain structures, including a conserved thermolysin-like core inserted between structurally distinct amino- and carboxy-terminal regions. Differences between TeNT-LC and the other CNT light chains are mainly limited to surface features such as unique electrostatic potential profiles. An analysis of surface residue conservation reveals a pattern of relatively high variability matching the path of substrate binding around BoNT/A, possibly serving to accommodate the variations in different SNARE targets of the CNT group.

About this Structure

1Z7H is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

Reference

2.3 A crystal structure of tetanus neurotoxin light chain., Breidenbach MA, Brunger AT, Biochemistry. 2005 May 24;44(20):7450-7. PMID:15895988 Page seeded by OCA on Sat May 3 17:16:30 2008

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