We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1z7j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1z7j.gif|left|200px]]
[[Image:1z7j.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1z7j |SIZE=350|CAPTION= <scene name='initialview01'>1z7j</scene>, resolution 2.20&Aring;
+
The line below this paragraph, containing "STRUCTURE_1z7j", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=T4A:3,3&#39;,5,5&#39;-TETRAIODOTHYROACETIC+ACID'>T4A</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1z7j| PDB=1z7j | SCENE= }}
-
|RELATEDENTRY=[[1pab|1PAB]], [[2rox|2ROX]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7j OCA], [http://www.ebi.ac.uk/pdbsum/1z7j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z7j RCSB]</span>
+
-
}}
+
'''Human transthyretin (also called prealbumin) complex with 3, 3',5,5'-tetraiodothyroacetic acid (t4ac)'''
'''Human transthyretin (also called prealbumin) complex with 3, 3',5,5'-tetraiodothyroacetic acid (t4ac)'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
1Z7J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1KED. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7J OCA].
+
1Z7J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ked 1ked]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7J OCA].
==Reference==
==Reference==
Line 28: Line 25:
[[Category: Neumann, P.]]
[[Category: Neumann, P.]]
[[Category: Wojtczak, A.]]
[[Category: Wojtczak, A.]]
-
[[Category: albumin]]
+
[[Category: Albumin]]
-
[[Category: amyloid]]
+
[[Category: Amyloid]]
-
[[Category: cerebrospinal fluid]]
+
[[Category: Cerebrospinal fluid]]
-
[[Category: disease mutation]]
+
[[Category: Disease mutation]]
-
[[Category: liver]]
+
[[Category: Liver]]
-
[[Category: plasma]]
+
[[Category: Plasma]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: polyneuropathy]]
+
[[Category: Polyneuropathy]]
-
[[Category: prealbumin]]
+
[[Category: Prealbumin]]
-
[[Category: retinol-binding]]
+
[[Category: Retinol-binding]]
-
[[Category: t4ac]]
+
[[Category: T4ac]]
-
[[Category: tetraiodothyroacetic acid]]
+
[[Category: Tetraiodothyroacetic acid]]
-
[[Category: thyroid hormone]]
+
[[Category: Thyroid hormone]]
-
[[Category: transport]]
+
[[Category: Transport]]
-
[[Category: vitamin some]]
+
[[Category: Vitamin some]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:16:35 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:31:18 2008''
+

Revision as of 14:16, 3 May 2008

Image:1z7j.gif

Template:STRUCTURE 1z7j

Human transthyretin (also called prealbumin) complex with 3, 3',5,5'-tetraiodothyroacetic acid (t4ac)


Overview

The crystal structure of the complex of human transthyretin (hTTR) with 3,3',5,5'-tetraiodothyroacetic acid (T4Ac) has been determined to 2.2 Angstrom resolution. The complex crystallizes in the orthorhombic space group P2(1)2(1)2, with unit-cell parameters a = 43.46, b = 85.85, c = 65.44 Angstrom. The structure was refined to R = 17.3% and R(free) = 21.9% for reflections without any sigma-cutoff. T4Ac is bound in both the forward and the reverse mode in the two binding sites of hTTR. In the forward orientation, T4Ac binds in a position similar to that described for thyroxine (T4) in the orthorhombic hTTR-T4 complex. In this orientation, the iodine substituents of the phenolic ring are bound in the P3'/P2 halogen pockets. In the reverse orientation, which is the major binding mode of T4Ac, the ligand is bound deep in the TTR channel, with the carboxylic group bound in the P3' pocket and forming simultaneous polar interactions with the residues constituting the two hormone-binding sites. Such interactions of a thyroxine-analogue ligand bound in the reverse mode have never been observed in TTR complexes previously.

About this Structure

1Z7J is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1ked. Full crystallographic information is available from OCA.

Reference

Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution., Neumann P, Cody V, Wojtczak A, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1313-9. Epub 2005, Sep 28. PMID:16204882 Page seeded by OCA on Sat May 3 17:16:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z7j"
Personal tools