2r9c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Calpain 1 proteolytic core inactivated by ZLAK-3001, an alpha-ketoamide==
==Calpain 1 proteolytic core inactivated by ZLAK-3001, an alpha-ketoamide==
-
<StructureSection load='2r9c' size='340' side='right' caption='[[2r9c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+
<StructureSection load='2r9c' size='340' side='right'caption='[[2r9c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2r9c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9C FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2r9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9C FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GRD:BENZYL+(S)-1-((2S,3S)-1-(3-(6-AMINO-9H-PURIN-9-YL)PROPYLAMINO)-2-HYDROXY-1-OXOPENTAN-3-YLAMINO)-4-METHYL-1-OXOPENTAN-2-YLCARBAMATE'>GRD</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GRD:BENZYL+(S)-1-((2S,3S)-1-(3-(6-AMINO-9H-PURIN-9-YL)PROPYLAMINO)-2-HYDROXY-1-OXOPENTAN-3-YLAMINO)-4-METHYL-1-OXOPENTAN-2-YLCARBAMATE'>GRD</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2g8j|2g8j]], [[1kxr|1kxr]], [[1tl9|1tl9]], [[1tlo|1tlo]], [[2g8e|2g8e]], [[2r9f|2r9f]]</td></tr>
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g8j|2g8j]], [[1kxr|1kxr]], [[1tl9|1tl9]], [[1tlo|1tlo]], [[2g8e|2g8e]], [[2r9f|2r9f]]</div></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capn1, Cls1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capn1, Cls1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] </span></td></tr>
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] </span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9c OCA], [http://pdbe.org/2r9c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r9c RCSB], [http://www.ebi.ac.uk/pdbsum/2r9c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9c ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9c OCA], [https://pdbe.org/2r9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9c RCSB], [https://www.ebi.ac.uk/pdbsum/2r9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CAN1_RAT CAN1_RAT]] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
+
[[https://www.uniprot.org/uniprot/CAN1_RAT CAN1_RAT]] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9c_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9c_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 31: Line 31:
</div>
</div>
<div class="pdbe-citations 2r9c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2r9c" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Calpain 3D structures|Calpain 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 36: Line 39:
</StructureSection>
</StructureSection>
[[Category: Calpain-1]]
[[Category: Calpain-1]]
 +
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Campbell, R L]]
[[Category: Campbell, R L]]

Revision as of 04:18, 2 July 2021

Calpain 1 proteolytic core inactivated by ZLAK-3001, an alpha-ketoamide

PDB ID 2r9c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r9c"
Personal tools