1zb1

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[[Image:1zb1.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zb1 OCA], [http://www.ebi.ac.uk/pdbsum/1zb1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zb1 RCSB]</span>
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'''Structure basis for endosomal targeting by the Bro1 domain'''
'''Structure basis for endosomal targeting by the Bro1 domain'''
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[[Category: Odorizzi, G.]]
[[Category: Odorizzi, G.]]
[[Category: Sitaraman, S.]]
[[Category: Sitaraman, S.]]
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[[Category: aip1]]
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[[Category: Aip1]]
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[[Category: bro1]]
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[[Category: Bro1]]
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[[Category: bro1 domain]]
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[[Category: Bro1 domain]]
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[[Category: snf7]]
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[[Category: Snf7]]
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[[Category: trafficking]]
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[[Category: Trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:24:19 2008''
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Revision as of 14:24, 3 May 2008

Image:1zb1.gif

Template:STRUCTURE 1zb1

Structure basis for endosomal targeting by the Bro1 domain


Overview

Proteins delivered to the lysosome or the yeast vacuole via late endosomes are sorted by the ESCRT complexes and by associated proteins, including Alix and its yeast homolog Bro1. Alix, Bro1, and several other late endosomal proteins share a conserved 160 residue Bro1 domain whose boundaries, structure, and function have not been characterized. The crystal structure of the Bro1 domain of Bro1 reveals a folded core of 367 residues. The extended Bro1 domain is necessary and sufficient for binding to the ESCRT-III subunit Snf7 and for the recruitment of Bro1 to late endosomes. The structure resembles a boomerang with its concave face filled in and contains a triple tetratricopeptide repeat domain as a substructure. Snf7 binds to a conserved hydrophobic patch on Bro1 that is required for protein complex formation and for the protein-sorting function of Bro1. These results define a conserved mechanism whereby Bro1 domain-containing proteins are targeted to endosomes by Snf7 and its orthologs.

About this Structure

1ZB1 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for endosomal targeting by the Bro1 domain., Kim J, Sitaraman S, Hierro A, Beach BM, Odorizzi G, Hurley JH, Dev Cell. 2005 Jun;8(6):937-47. PMID:15935782 Page seeded by OCA on Sat May 3 17:24:19 2008

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