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3dal
From Proteopedia
(Difference between revisions)
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==Methyltransferase domain of human PR domain-containing protein 1== | ==Methyltransferase domain of human PR domain-containing protein 1== | ||
| - | <StructureSection load='3dal' size='340' side='right' caption='[[3dal]], [[Resolution|resolution]] 1.65Å' scene=''> | + | <StructureSection load='3dal' size='340' side='right'caption='[[3dal]], [[Resolution|resolution]] 1.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3dal]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3dal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAL FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDM1, BLIMP1 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDM1, BLIMP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dal OCA], [https://pdbe.org/3dal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dal RCSB], [https://www.ebi.ac.uk/pdbsum/3dal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dal ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PRDM1_HUMAN PRDM1_HUMAN]] Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dal_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dal_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Amaya, M F]] | [[Category: Amaya, M F]] | ||
[[Category: Antoshenko, T]] | [[Category: Antoshenko, T]] | ||
Revision as of 07:58, 2 February 2022
Methyltransferase domain of human PR domain-containing protein 1
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Categories: Human | Large Structures | Amaya, M F | Antoshenko, T | Arrowsmith, C H | Bochkarev, A | Bountra, C | Dong, A | Edwards, A M | Loppnau, P | Min, J | Plotnikov, A N | Structural genomic | Weigelt, J | Wu, H | Zeng, H | Dna binding protein | Dna-binding | Metal-binding | Methyltransferase | Nucleus | Polymorphism | Prdm1 | Repressor | Sgc | Transcription | Transcription regulation | Transferase | Zinc | Zinc-finger
