3dav

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==Schizosaccharomyces Pombe Profilin crystallized from Sodium formate==
==Schizosaccharomyces Pombe Profilin crystallized from Sodium formate==
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<StructureSection load='3dav' size='340' side='right' caption='[[3dav]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3dav' size='340' side='right'caption='[[3dav]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dav]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dav]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d9y|3d9y]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d9y|3d9y]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdc3, SPAC4A8.15c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdc3, SPAC4A8.15c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dav OCA], [http://pdbe.org/3dav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dav RCSB], [http://www.ebi.ac.uk/pdbsum/3dav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dav ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dav OCA], [https://pdbe.org/3dav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dav RCSB], [https://www.ebi.ac.uk/pdbsum/3dav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dav ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PROF_SCHPO PROF_SCHPO]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.
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[[https://www.uniprot.org/uniprot/PROF_SCHPO PROF_SCHPO]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dav_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dav_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3dav" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3dav" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Profilin 3D Structures|Profilin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Cbs 356]]
[[Category: Cbs 356]]
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[[Category: Large Structures]]
[[Category: Ezezika, O C]]
[[Category: Ezezika, O C]]
[[Category: Nolen, B J]]
[[Category: Nolen, B J]]

Revision as of 07:59, 2 February 2022

Schizosaccharomyces Pombe Profilin crystallized from Sodium formate

PDB ID 3dav

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