1zdm

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[[Image:1zdm.gif|left|200px]]
[[Image:1zdm.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zdm |SIZE=350|CAPTION= <scene name='initialview01'>1zdm</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1zdm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XE:XENON'>XE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= cheY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1zdm| PDB=1zdm | SCENE= }}
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|RELATEDENTRY=[[1fqw|1FQW]], [[1f4v|1F4V]], [[1djm|1DJM]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zdm OCA], [http://www.ebi.ac.uk/pdbsum/1zdm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zdm RCSB]</span>
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}}
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'''Crystal Structure of Activated CheY Bound to Xe'''
'''Crystal Structure of Activated CheY Bound to Xe'''
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[[Category: Ruiz, E J.]]
[[Category: Ruiz, E J.]]
[[Category: Wemmer, D E.]]
[[Category: Wemmer, D E.]]
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[[Category: activated chey]]
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[[Category: Activated chey]]
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[[Category: bef3]]
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[[Category: Bef3]]
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[[Category: protein cavity]]
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[[Category: Protein cavity]]
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[[Category: protein conformation assay]]
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[[Category: Protein conformation assay]]
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[[Category: response regulator]]
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[[Category: Response regulator]]
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[[Category: xenon binding]]
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[[Category: Xenon binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:29:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:34:32 2008''
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Revision as of 14:29, 3 May 2008

Image:1zdm.gif

Template:STRUCTURE 1zdm

Crystal Structure of Activated CheY Bound to Xe


Overview

The chemical shift of the (129)Xe NMR signal has been shown to be extremely sensitive to the local environment around the atom and has been used to follow processes such as ligand binding by bacterial periplasmic binding proteins. Here we show that the (129)Xe shift can sense more subtle changes: magnesium binding, BeF(3)(-) activation, and peptide binding by the Escherichia coli chemotaxis Y protein. (1)H-(15)N correlation spectroscopy and X-ray crystallography were used to identify two xenon-binding cavities in CheY that are primarily responsible for the shift changes. One site is near the active site, and the other is near the peptide binding site.

About this Structure

1ZDM is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Distinguishing multiple chemotaxis Y protein conformations with laser-polarized 129Xe NMR., Lowery TJ, Doucleff M, Ruiz EJ, Rubin SM, Pines A, Wemmer DE, Protein Sci. 2005 Apr;14(4):848-55. Epub 2005 Mar 1. PMID:15741343 Page seeded by OCA on Sat May 3 17:29:52 2008

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