3eay

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==Crystal structure of the human SENP7 catalytic domain==
==Crystal structure of the human SENP7 catalytic domain==
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<StructureSection load='3eay' size='340' side='right' caption='[[3eay]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3eay' size='340' side='right'caption='[[3eay]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3eay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3eay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SENP7, KIAA1707, SSP2, SUSP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SENP7, KIAA1707, SSP2, SUSP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eay OCA], [http://pdbe.org/3eay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eay RCSB], [http://www.ebi.ac.uk/pdbsum/3eay PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eay ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eay OCA], [https://pdbe.org/3eay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eay RCSB], [https://www.ebi.ac.uk/pdbsum/3eay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eay ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SENP7_HUMAN SENP7_HUMAN]] Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.<ref>PMID:18799455</ref>
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[[https://www.uniprot.org/uniprot/SENP7_HUMAN SENP7_HUMAN]] Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.<ref>PMID:18799455</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eay_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eay_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3eay" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3eay" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sentrin-specific protease|Sentrin-specific protease]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Lima, C D]]
[[Category: Lima, C D]]
[[Category: Reverter, D]]
[[Category: Reverter, D]]

Revision as of 11:45, 16 February 2022

Crystal structure of the human SENP7 catalytic domain

PDB ID 3eay

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