1zgs
From Proteopedia
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'''Parkia platycephala seed lectin in complex with 5-bromo-4-chloro-3-indolyl-a-D-mannose''' | '''Parkia platycephala seed lectin in complex with 5-bromo-4-chloro-3-indolyl-a-D-mannose''' | ||
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[[Category: Cavada, B S.]] | [[Category: Cavada, B S.]] | ||
[[Category: Sol, F Gallego del.]] | [[Category: Sol, F Gallego del.]] | ||
| - | [[Category: | + | [[Category: Beta prism]] |
| - | [[Category: | + | [[Category: Lectin]] |
| - | [[Category: | + | [[Category: X-man]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:36:19 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:36, 3 May 2008
Parkia platycephala seed lectin in complex with 5-bromo-4-chloro-3-indolyl-a-D-mannose
Overview
The crystal structures of the apo and mannose-bound Parkia platycephala seed lectin represent the first structure of a Mimosoideae lectin and a novel circular arrangement of beta-prism domains, and highlight the adaptability of the beta-prism fold as a building block in the evolution of plant lectins. The P.platycephala lectin is a dimer both in solution and in the crystals. Mannose binding to each of the three homologous carbohydrate-recognition domains of the lectin occurs through different modes, and restrains the flexibility of surface-exposed loops and residues involved in carbohydrate recognition. The planar array of carbohydrate-binding sites on the rim of the toroid-shaped structure of the P.platycephala lectin dimer immediately suggests a mechanism to promote multivalent interactions leading to cross-linking of carbohydrate ligands as part of the host strategy against phytopredators and pathogens. The cyclic structure of the P.platycephala lectin points to the convergent evolution of a structural principle for the construction of lectins involved in host defense or in attacking other organisms.
About this Structure
1ZGS is a Single protein structure of sequence from Parkia platycephala. Full crystallographic information is available from OCA.
Reference
The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain., Gallego del Sol F, Nagano C, Cavada BS, Calvete JJ, J Mol Biol. 2005 Oct 28;353(3):574-83. Epub 2005 Sep 9. PMID:16185708 Page seeded by OCA on Sat May 3 17:36:19 2008
