Tryptophan synthase

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<StructureSection load='' size='400' side='right' caption='Tryptophan synthase α subunit (yellow, salmon) and β subunit (cyan, green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) [[1wbj]]' scene='52/525189/Cv/5'>
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<StructureSection load='' size='350' side='right' caption='Tryptophan synthase α subunit (yellow, salmon) and β subunit (cyan, green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) [[1wbj]]' scene='52/525189/Cv/5'>
== Function ==
== Function ==
'''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan<ref>PMID:11893063</ref>. TrpS '''α subunit''' catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The '''β subunit''' catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits.
'''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan<ref>PMID:11893063</ref>. TrpS '''α subunit''' catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The '''β subunit''' catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits.
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**[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
**[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
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**[[2dh6]] - EcTrpS β subunit]] - ''Escherichia coli''<br />
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**[[2dh6]] - EcTrpS β subunit - ''Escherichia coli''<br />
**[[2o2e]], [[2o2j]] - MtTrpS β subunit – ''Mycobacterium tuberculosis''<br />
**[[2o2e]], [[2o2j]] - MtTrpS β subunit – ''Mycobacterium tuberculosis''<br />
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**[[1v8z]] - PfTrpS β subunit <br />
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**[[1v8z]] - PfTrpS β1 subunit <br />
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
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**[[4qys]] - TrpS β subunit – ''Sulfolobus solfataricus''<br />
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**[[4qys]] - SsTrpS β2 subunit – ''Sulfolobus solfataricus''<br />
*Tryptophan synthase β complex
*Tryptophan synthase β complex
**[[2dh5]] - EcTrpS β subunit + PLP<br />
**[[2dh5]] - EcTrpS β subunit + PLP<br />
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**[[5dvz]] - PfTrpS β subunit + PLP derivative <br />
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**[[6eqn]] - SsTrpS β2 subunit + PLP<br />
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**[[5dw0]] - PfTrpS β subunit + Ser derivative <br />
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**[[5dvz]] - PfTrpS β1 subunit + PLP derivative <br />
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**[[5dw3]] - PfTrpS β subunit + PLP derivative + Trp<br />
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**[[6am7]], [[6amc]], [[6cuv]] - PfTrpS β1 subunit (mutant) + PLP derivative <br />
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**[[5t6m]] - PfTrpS β subunit + PLP derivative + Trp derivative<br />
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**[[5dw0]] - PfTrpS β1 subunit + Ser derivative <br />
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**[[5vm5]] - PfTrpS β subunit + PLP derivative + Ser derivative<br />
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**[[5dw3]] - PfTrpS β1 subunit + PLP derivative + Trp<br />
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**[[5ixj]] - PfTrpS β subunit + PLP derivative + Thr<br />
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**[[6am8]], [[6ami]] - PfTrpS β1 subunit (mutant) + PLP derivative + Trp<br />
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**[[5t6m]] - PfTrpS β1 subunit + PLP derivative + Trp derivative<br />
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**[[5vm5]] - PfTrpS β1 subunit + PLP derivative + Ser derivative<br />
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**[[5ixj]] - PfTrpS β1 subunit + PLP derivative + Thr<br />
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**[[6am9]], [[6amh]] - PfTrpS β1 subunit (mutant) + PLP-Ser derivative <br />
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**[[6cut]] - PfTrpS β1 subunit (mutant) + Trp analog <br />
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**[[6cuz]] - PfTrpS β1 subunit (mutant) + PLP derivative + ethylserine<br />
*'''Tryptophan synthase α+β subunits'''
*'''Tryptophan synthase α+β subunits'''
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**[[5cgq]] - StTrpS α + β + Trp + inhibitor + PLP<br />
**[[5cgq]] - StTrpS α + β + Trp + inhibitor + PLP<br />
**[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br />
**[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br />
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**[[6du1]], [[6dua]], [[6dwe]], [[6e9p]] - MtTrpS α + β + malonate + inhibitor + PLP derivative<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 17:07, 28 September 2018

Tryptophan synthase α subunit (yellow, salmon) and β subunit (cyan, green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) 1wbj

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3D structures of tryptophan synthase

Updated on 28-September-2018

References

  1. ↑ Miles EW. Tryptophan synthase: a multienzyme complex with an intramolecular tunnel. Chem Rec. 2001;1(2):140-51. PMID:11893063
  2. ↑ Shen H, Yang Y, Wang F, Zhang Y, Ye N, Xu S, Wang H. Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis. Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):379-88. PMID:19430702
  3. ↑ Kulik V, Hartmann E, Weyand M, Frey M, Gierl A, Niks D, Dunn MF, Schlichting I. On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. J Mol Biol. 2005 Sep 23;352(3):608-20. PMID:16120446 doi:10.1016/j.jmb.2005.07.014

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Amer Ali

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