This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5wbs
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21== | |
| - | + | <StructureSection load='5wbs' size='340' side='right' caption='[[5wbs]], [[Resolution|resolution]] 2.88Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wbs]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WBS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wbs OCA], [http://pdbe.org/5wbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wbs RCSB], [http://www.ebi.ac.uk/pdbsum/5wbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wbs ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hannoush, R N]] | ||
[[Category: Mukund, S]] | [[Category: Mukund, S]] | ||
| + | [[Category: Nile, A H]] | ||
[[Category: Wang, W]] | [[Category: Wang, W]] | ||
| - | [[Category: | + | [[Category: Dimerization]] |
| - | [[Category: | + | [[Category: Frizzled]] |
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Wnt signaling]] | ||
Revision as of 05:39, 18 April 2018
Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21
| |||||||||||
