5wbs
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21== | |
| - | + | <StructureSection load='5wbs' size='340' side='right' caption='[[5wbs]], [[Resolution|resolution]] 2.88Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wbs]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WBS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wbs OCA], [http://pdbe.org/5wbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wbs RCSB], [http://www.ebi.ac.uk/pdbsum/5wbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wbs ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hannoush, R N]] | ||
[[Category: Mukund, S]] | [[Category: Mukund, S]] | ||
| + | [[Category: Nile, A H]] | ||
[[Category: Wang, W]] | [[Category: Wang, W]] | ||
| - | [[Category: | + | [[Category: Dimerization]] |
| - | [[Category: | + | [[Category: Frizzled]] |
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Wnt signaling]] | ||
Revision as of 05:39, 18 April 2018
Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21
| |||||||||||
