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1ziw

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[[Image:1ziw.gif|left|200px]]
[[Image:1ziw.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ziw |SIZE=350|CAPTION= <scene name='initialview01'>1ziw</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1ziw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= TLR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1ziw| PDB=1ziw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ziw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ziw OCA], [http://www.ebi.ac.uk/pdbsum/1ziw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ziw RCSB]</span>
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'''Human Toll-like Receptor 3 extracellular domain structure'''
'''Human Toll-like Receptor 3 extracellular domain structure'''
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[[Category: Choe, J.]]
[[Category: Choe, J.]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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[[Category: innate immunity]]
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[[Category: Innate immunity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:40:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:37:16 2008''
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Revision as of 14:40, 3 May 2008

Image:1ziw.gif

Template:STRUCTURE 1ziw

Human Toll-like Receptor 3 extracellular domain structure


Overview

Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA.

About this Structure

1ZIW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain., Choe J, Kelker MS, Wilson IA, Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:15961631 Page seeded by OCA on Sat May 3 17:40:51 2008

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