1zk6

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[[Image:1zk6.gif|left|200px]]
[[Image:1zk6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zk6 |SIZE=350|CAPTION= <scene name='initialview01'>1zk6</scene>
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The line below this paragraph, containing "STRUCTURE_1zk6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= prsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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|DOMAIN=
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{{STRUCTURE_1zk6| PDB=1zk6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zk6 OCA], [http://www.ebi.ac.uk/pdbsum/1zk6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zk6 RCSB]</span>
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'''NMR solution structure of B. subtilis PrsA PPIase'''
'''NMR solution structure of B. subtilis PrsA PPIase'''
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[[Category: Seppala, R.]]
[[Category: Seppala, R.]]
[[Category: Tossavainen, H.]]
[[Category: Tossavainen, H.]]
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[[Category: alpha/beta structure]]
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[[Category: Alpha/beta structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:43:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:37:47 2008''
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Revision as of 14:43, 3 May 2008

Image:1zk6.gif

Template:STRUCTURE 1zk6

NMR solution structure of B. subtilis PrsA PPIase


Overview

PrsA is a peptidyl-prolyl isomerase (PPIase) from Bacillus subtilis belonging to the parvulin family of PPIases. It is a membrane bound lipoprotein at the membrane-wall interface, involved in folding of exported proteins. We present the NMR solution structure of the PPIase domain of PrsA, the first from a Gram-positive bacterium. In addition we mapped out the active site with NMR titration experiments. A high degree of conservation with other members of the parvulin family was revealed in the structure and binding site. Interactions with substrate peptides were also characterized by mutated domains revealing that H122 is indispensable for overall correct folding.

About this Structure

1ZK6 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

NMR solution structure and characterization of substrate binding site of the PPIase domain of PrsA protein from Bacillus subtilis., Tossavainen H, Permi P, Purhonen SL, Sarvas M, Kilpelainen I, Seppala R, FEBS Lett. 2006 Mar 20;580(7):1822-6. Epub 2006 Feb 24. PMID:16516208 Page seeded by OCA on Sat May 3 17:43:23 2008

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