1zlc
From Proteopedia
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[[Image:1zlc.gif|left|200px]] | [[Image:1zlc.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_1zlc| PDB=1zlc | SCENE= }} | |
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'''Solution Conformation of alpha-conotoxin PIA''' | '''Solution Conformation of alpha-conotoxin PIA''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZLC is a [[Single protein]] structure | + | 1ZLC is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: McIntosh, J M.]] | [[Category: McIntosh, J M.]] | ||
[[Category: Olivera, B M.]] | [[Category: Olivera, B M.]] | ||
| - | [[Category: | + | [[Category: Alpha-helix]] |
| - | [[Category: | + | [[Category: Beta-turn]] |
| - | [[Category: | + | [[Category: C-terminal amidation]] |
| - | [[Category: | + | [[Category: Two disulfide bond]] |
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Revision as of 14:46, 3 May 2008
Solution Conformation of alpha-conotoxin PIA
Overview
alpha-Conotoxin PIA is a novel nicotinic acetylcholine receptor (nAChR) antagonist isolated from Conus purpurascens that targets nAChR subtypes containing alpha6 and alpha3 subunits. alpha-conotoxin PIA displays 75-fold higher affinity for rat alpha6/alpha3beta2beta3 nAChRs than for rat alpha3beta2 nAChRs. We have determined the three-dimensional structure of alpha-conotoxin PIA by nuclear magnetic resonance spectroscopy. The alpha-conotoxin PIA has an "omega-shaped" overall topology as other alpha4/7 subfamily conotoxins. Yet, unlike other neuronally targeted alpha4/7-conotoxins, its N-terminal tail Arg1-Asp2-Pro3 protrudes out of its main molecular body because Asp2-Pro3-Cys4-Cys5 forms a stable type I beta-turn. In addition, a kink introduced by Pro15 in the second loop of this toxin provides a distinct steric and electrostatic environment from those in alpha-conotoxins MII and GIC. By comparing the structure of alpha-conotoxin PIA with other functionally related alpha-conotoxins we suggest structural features in alpha-conotoxin PIA that may be associated with its unique receptor recognition profile.
About this Structure
1ZLC is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors., Chi SW, Lee SH, Kim DH, Kim JS, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2005 Dec 30;338(4):1990-7. Epub 2005 Nov 7. PMID:16289101 Page seeded by OCA on Sat May 3 17:45:59 2008
