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5ogl

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Current revision (16:49, 13 December 2023) (edit) (undo)
 
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==Structure of bacterial oligosaccharyltransferase PglB in complex with an acceptor peptide and an lipid-linked oligosaccharide analog==
==Structure of bacterial oligosaccharyltransferase PglB in complex with an acceptor peptide and an lipid-linked oligosaccharide analog==
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<StructureSection load='5ogl' size='340' side='right' caption='[[5ogl]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='5ogl' size='340' side='right'caption='[[5ogl]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ogl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camlr Camlr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OGL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ogl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni] and [https://en.wikipedia.org/wiki/Campylobacter_lari_RM2100 Campylobacter lari RM2100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OGL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9UB:[(2~{S},3~{R},4~{R},5~{S},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]methyl-[oxidanyl-[(2~{Z},6~{Z},10~{Z})-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenoxy]phosphoryl]oxy-phosphinic+acid'>9UB</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PPN:PARA-NITROPHENYLALANINE'>PPN</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9UB:[(2~{S},3~{R},4~{R},5~{S},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]methyl-[oxidanyl-[(2~{Z},6~{Z},10~{Z})-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenoxy]phosphoryl]oxy-phosphinic+acid'>9UB</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPN:PARA-NITROPHENYLALANINE'>PPN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pglB, Cla_1253 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=306263 CAMLR])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ogl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ogl OCA], [https://pdbe.org/5ogl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ogl RCSB], [https://www.ebi.ac.uk/pdbsum/5ogl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ogl ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.19 2.4.99.19] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ogl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ogl OCA], [http://pdbe.org/5ogl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ogl RCSB], [http://www.ebi.ac.uk/pdbsum/5ogl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ogl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PGLB_CAMLR PGLB_CAMLR]] Oligosaccharyltransferase that catalyzes the transfer of a preassembled heptasaccharide from a lipid donor to an asparagine residue in nascent polypeptide chains, affording a beta-linked glycan to the asparagine side chain of target proteins.<ref>PMID:21677752</ref>
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[https://www.uniprot.org/uniprot/PGLB_CAMLR PGLB_CAMLR] Oligosaccharyltransferase that catalyzes the transfer of a preassembled heptasaccharide from a lipid donor to an asparagine residue in nascent polypeptide chains, affording a beta-linked glycan to the asparagine side chain of target proteins.<ref>PMID:21677752</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Camlr]]
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[[Category: Campylobacter jejuni]]
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[[Category: Transferase]]
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[[Category: Campylobacter lari RM2100]]
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[[Category: Aebi, M]]
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[[Category: Large Structures]]
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[[Category: Boilevin, J]]
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[[Category: Aebi M]]
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[[Category: Darbre, T]]
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[[Category: Boilevin J]]
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[[Category: Locher, K P]]
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[[Category: Darbre T]]
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[[Category: Napiorkowska, M]]
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[[Category: Locher KP]]
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[[Category: Reymond, J L]]
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[[Category: Napiorkowska M]]
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[[Category: Sovdat, T]]
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[[Category: Reymond J-L]]
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[[Category: Bacteria]]
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[[Category: Sovdat T]]
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[[Category: Complex]]
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[[Category: Membrane protein]]
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[[Category: Oligosaccharyltransferase]]
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[[Category: Protein n-glycosylation]]
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Current revision

Structure of bacterial oligosaccharyltransferase PglB in complex with an acceptor peptide and an lipid-linked oligosaccharide analog

PDB ID 5ogl

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